{"id":"W2590149856","doi":"10.1200/jco.2005.23.16_suppl.5539","title":"A phase I open-label study to evaluate safety, tolerability and pharmacokinetic (PK) profile of VB4–845, an anti-EpCAM immunotoxin, in subjects with SCCHN","year":2005,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Toxin Mechanisms and Immunotoxins","field":"Immunology and Microbiology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Viventia Bio (Canada)","funders":"","keywords":"Medicine; Tolerability; Pharmacokinetics; Immunogenicity; Epithelial cell adhesion molecule; Internal medicine; Pharmacodynamics; Lesion; Cancer; Pharmacology; Oncology; Pathology; Antibody; Adverse effect; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.009504183,0.0003174734,0.002407196,0.0002629135,0.0001330032,0.0000320435,0.0009233112,0.0003892203,0.0006889896],"category_scores_gemma":[0.001223778,0.0002298205,0.0001241822,0.0003385903,0.0004944594,0.0004759484,0.0003566325,0.00139315,0.00004030502],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001047415,"about_ca_system_score_gemma":0.001275052,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009616684,"about_ca_topic_score_gemma":0.0003436433,"domain_scores_codex":[0.9926697,0.002594889,0.003564058,0.0005175406,0.000149943,0.000503872],"domain_scores_gemma":[0.9959627,0.001048485,0.001798507,0.0004934463,0.0005120131,0.0001848974],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.04626508,0.1120498,0.03031613,0.00003919878,0.001006577,0.0002108872,0.003591537,0.0001351266,0.4438607,0.0001448275,0.0004314863,0.3619487],"study_design_scores_gemma":[0.2685356,0.3069874,0.3484087,0.0003359105,0.0008494348,0.0007636103,0.00313261,0.0001960126,0.05258222,0.0002701329,0.01708043,0.0008579846],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947861,0.001079187,0.0001251711,0.0009395842,0.0008551727,0.001755382,0.00003036941,0.00001146643,0.0004175779],"genre_scores_gemma":[0.9953555,0.0001885949,0.003482539,0.0005702174,0.0001215143,0.00002823129,0.000007167152,0.00002969302,0.0002165524],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3912784,"threshold_uncertainty_score":0.9371806,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1048210451626434,"score_gpt":0.4724052317314485,"score_spread":0.3675841865688051,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}