{"id":"W2590149856","doi":"10.1200/jco.2005.23.16_suppl.5539","title":"A phase I open-label study to evaluate safety, tolerability and pharmacokinetic (PK) profile of VB4–845, an anti-EpCAM immunotoxin, in subjects with SCCHN","year":2005,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Toxin Mechanisms and Immunotoxins","field":"Immunology and Microbiology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Viventia Bio (Canada)","funders":"","keywords":"Medicine; Tolerability; Pharmacokinetics; Immunogenicity; Epithelial cell adhesion molecule; Internal medicine; Pharmacodynamics; Lesion; Cancer; Pharmacology; Oncology; Pathology; Antibody; Adverse effect; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008574128,0.0008805429,0.001236775,0.0002826122,0.000376255,0.0005865222,0.0005579168,0.0007256617,0.003235622],"category_scores_gemma":[0.0004480424,0.0004134319,0.0006001115,0.0002334679,0.0007115894,0.0005945888,0.0002070019,0.001831843,0.0007608439],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007789562,"about_ca_system_score_gemma":0.001210634,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001015498,"about_ca_topic_score_gemma":0.002093042,"domain_scores_codex":[0.9997342,0.00008907452,0.00001107529,0.00006644331,0.00003652447,0.00006263883],"domain_scores_gemma":[0.9995325,0.00005402913,0.0001022943,0.00004653233,0.00004234765,0.0002222855],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5454736,0.1653506,0.007724996,0.0006111662,0.0007712964,0.0002853918,0.0003889684,0.002197794,0.187129,0.0002490834,0.002806197,0.08701187],"study_design_scores_gemma":[0.1142838,0.8644635,0.01233968,0.00001839215,0.0002005625,0.0001506448,0.00006483577,0.0008466197,0.005379444,0.0001153183,0.002120042,0.00001710953],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958878,0.0006094033,0.0005261507,0.00008336417,0.00005231319,0.001619423,0.0004687878,0.00005567324,0.00069695],"genre_scores_gemma":[0.9921976,0.0005999441,0.001212857,0.0003589971,0.0000852214,0.001732714,0.0009511424,0.00002003601,0.002841373],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003235622,"threshold_uncertainty_score":0.0108242,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1048210451626434,"score_gpt":0.4724052317314485,"score_spread":0.3675841865688051,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}