{"id":"W2590224899","doi":"10.1111/epi.13710","title":"Carisbamate blockade of T‐type voltage‐gated calcium channels","year":2017,"lang":"en","type":"article","venue":"Epilepsia","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Libin Cardiovascular Institute of Alberta; Alberta Children's Hospital; Hotchkiss Brain Institute; University of Calgary","funders":"National Institute of Neurological Disorders and Stroke; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Alberta Children's Hospital Foundation; Johnson and Johnson; Canada Foundation for Innovation; National Institutes of Health; Barrow Neurological Foundation; Heart and Stroke Foundation of Canada","keywords":"Kainic acid; Neuroprotection; Glutamate receptor; Chemistry; T-type calcium channel; Hippocampal formation; Mitochondrial permeability transition pore; Voltage-dependent calcium channel; Membrane potential; Calcium; Mitochondrion; Cell biology; Pharmacology; Biology; Neuroscience; Biochemistry; Apoptosis; Programmed cell death; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001100261,0.0005180947,0.000277802,0.0002483854,0.0001392956,0.0002840918,0.0003773572,0.0003616487,0.003197525],"category_scores_gemma":[0.0001528668,0.00008746871,0.0002045085,0.0001261711,0.0002108157,0.0002295159,0.0001509715,0.0006164399,0.0004272032],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003873853,"about_ca_system_score_gemma":0.0003423702,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001350762,"about_ca_topic_score_gemma":0.00198521,"domain_scores_codex":[0.9999043,0.00001361126,0.000008792189,0.000014877,0.00001639234,0.00004192339],"domain_scores_gemma":[0.9999058,0.00001621165,0.00002801224,0.00001024095,0.00001647554,0.00002329863],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003944266,0.0000800614,0.0001384134,0.0001294707,0.00001648289,0.0001073138,0.00001571378,0.0001024599,0.9945652,0.0002083031,0.0001499911,0.004092101],"study_design_scores_gemma":[0.0002706969,0.002228142,0.004054189,0.00001673932,0.00004256628,0.0003753322,0.00002886195,0.001217219,0.9867517,0.00007603436,0.004932066,0.000006383009],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9887572,0.003661209,0.001802164,0.0002575715,0.0000716326,0.0001164072,0.0002638167,0.0003378527,0.004732111],"genre_scores_gemma":[0.9951095,0.00142532,0.0007024278,0.00007390245,0.00002704852,0.00005615471,0.0001617809,0.00001135668,0.002432601],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003197525,"threshold_uncertainty_score":0.01069677,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1172687145054745,"score_gpt":0.3904216489349531,"score_spread":0.2731529344294786,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}