{"id":"W2590252333","doi":"10.1021/acs.molpharmaceut.6b01119","title":"Self-Associating Poly(ethylene oxide)-<i>block</i>-poly(α-carboxyl-ε-caprolactone) Drug Conjugates for the Delivery of STAT3 Inhibitor JSI-124: Potential Application in Cancer Immunotherapy","year":2017,"lang":"en","type":"article","venue":"Molecular Pharmaceutics","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Tata Trusts; Canadian Institutes of Health Research; Alberta Innovates - Health Solutions; Alberta Cancer Foundation","keywords":"Chemistry; Nanocarriers; Cancer immunotherapy; Micelle; Ethylene oxide; STAT3; Tumor microenvironment; Drug delivery; Cancer research; Immunotherapy; Immune system; Pharmacology; Biochemistry; Medicine; Phosphorylation; Polymer; Immunology; Organic chemistry; Copolymer; Aqueous solution","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0009205884,0.0003582794,0.0004893456,0.0001279623,0.0006723022,0.00007911112,0.0008579584,0.0002825272,0.00002318522],"category_scores_gemma":[0.00007803774,0.0003090877,0.0002444835,0.0001190005,0.0003839227,0.0001818816,0.0001599797,0.0005322939,0.00001062445],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001503814,"about_ca_system_score_gemma":0.0002348826,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001663085,"about_ca_topic_score_gemma":0.00007045625,"domain_scores_codex":[0.9977787,0.0004054242,0.0006712757,0.0003849936,0.0001187049,0.0006409098],"domain_scores_gemma":[0.997795,0.0003668009,0.0007939511,0.0007886649,0.0002296942,0.00002585188],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001703745,0.000298363,0.001189854,0.00006521065,0.0009273064,0.000003546511,0.001008208,0.00005262321,0.9651299,0.000133986,0.00008344765,0.02940378],"study_design_scores_gemma":[0.005889974,0.0001045762,0.002662984,0.00006038538,0.0001908819,0.00000938294,0.0002464263,0.000852964,0.9549229,0.00008616433,0.03463396,0.0003393611],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8691903,0.1257923,0.001417317,0.001225325,0.0007859581,0.001337325,0.0001200197,0.00009274555,0.00003874734],"genre_scores_gemma":[0.9890965,0.009116638,0.0003824521,0.0006526452,0.00005596044,0.0003259762,0.00003746333,0.00009480498,0.0002375736],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1199062,"threshold_uncertainty_score":0.9999361,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01453364098883477,"score_gpt":0.3021591707594822,"score_spread":0.2876255297706474,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}