{"id":"W2590252333","doi":"10.1021/acs.molpharmaceut.6b01119","title":"Self-Associating Poly(ethylene oxide)-<i>block</i>-poly(α-carboxyl-ε-caprolactone) Drug Conjugates for the Delivery of STAT3 Inhibitor JSI-124: Potential Application in Cancer Immunotherapy","year":2017,"lang":"en","type":"article","venue":"Molecular Pharmaceutics","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Tata Trusts; Canadian Institutes of Health Research; Alberta Innovates - Health Solutions; Alberta Cancer Foundation","keywords":"Chemistry; Nanocarriers; Cancer immunotherapy; Micelle; Ethylene oxide; STAT3; Tumor microenvironment; Drug delivery; Cancer research; Immunotherapy; Immune system; Pharmacology; Biochemistry; Medicine; Phosphorylation; Polymer; Immunology; Organic chemistry; Copolymer; Aqueous solution","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009073514,0.0002832002,0.0001544741,0.0001287996,0.00006729922,0.0001543047,0.0001339262,0.000244054,0.0005191097],"category_scores_gemma":[0.00008478355,0.0001057093,0.000163837,0.0001175357,0.000125229,0.000196056,0.00009704524,0.0002650596,0.0002677479],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002154893,"about_ca_system_score_gemma":0.0001401177,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002035566,"about_ca_topic_score_gemma":0.0002311315,"domain_scores_codex":[0.9999496,0.000007555039,0.000004474744,0.00001289567,0.00001529534,0.00001021877],"domain_scores_gemma":[0.9999577,0.000006014852,0.00001706037,0.000002818787,0.00000592755,0.00001045064],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004393758,0.00002049376,0.00003457245,0.00003381367,0.000002798261,0.00002079544,0.000004800466,0.0001316387,0.998285,0.00003955569,0.00002630282,0.001356266],"study_design_scores_gemma":[0.00001123725,0.0002513605,0.0004497949,0.000002217337,0.000008869154,0.0000803664,0.000002145316,0.0009848378,0.9970858,0.00000909044,0.001110997,0.000003219684],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9837952,0.002388972,0.01127985,0.0001125704,0.00004379784,0.00008131614,0.000146604,0.0001758747,0.00197593],"genre_scores_gemma":[0.9891835,0.001275543,0.006847271,0.00006384718,0.00001712414,0.00005382001,0.000198572,0.00002413086,0.002336124],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005191097,"threshold_uncertainty_score":0.001736581,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01453364098883477,"score_gpt":0.3021591707594822,"score_spread":0.2876255297706474,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}