{"id":"W2590286012","doi":"10.1200/jco.2016.34.4_suppl.208","title":"Age barrier in clinical trials: Are we truly moving forward?","year":2016,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Clinical trial; Age limit; Inclusion and exclusion criteria; Internal medicine; Pediatrics; Gastroenterology; Pathology; Demography; Alternative medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":["metaresearch"],"category_scores_codex":[0.6668497,0.001506908,0.006990017,0.005167079,0.003830381,0.02055575,0.006004828,0.01107564,0.01555597],"category_scores_gemma":[0.7590819,0.002188888,0.004688985,0.00645757,0.01434147,0.03605899,0.01292094,0.01928624,0.003666672],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.011868,"about_ca_system_score_gemma":0.03966855,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002655763,"about_ca_topic_score_gemma":0.003424866,"domain_scores_codex":[0.3570807,0.4975787,0.08578078,0.0136718,0.04010539,0.005782548],"domain_scores_gemma":[0.07975186,0.7801431,0.07085361,0.02222637,0.03636033,0.0106648],"domain_codex":"methods","domain_gemma":"methods","domain_candidate":"methods","domain_consensus":"methods","study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.006513178,0.0004761213,0.04042532,0.05045591,0.003988607,0.0007612829,0.01080679,0.001980415,0.0008839461,0.1297961,0.1794589,0.5744534],"study_design_scores_gemma":[0.002739828,0.002990561,0.02483311,0.139517,0.002818148,0.00165825,0.007150928,0.002869041,0.001170585,0.2119643,0.601677,0.0006112175],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.008727216,0.1280131,0.01976759,0.813211,0.01906873,0.001531113,0.0006799346,0.0002255531,0.008775741],"genre_scores_gemma":[0.1666359,0.07502205,0.06695025,0.6406572,0.03784448,0.008439932,0.0009312252,0.0005491757,0.002969662],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.3331503,"threshold_uncertainty_score":0.4108337,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1842666580880661,"score_gpt":0.499842697177366,"score_spread":0.3155760390892999,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}