{"id":"W2590291063","doi":"10.18632/oncotarget.15471","title":"The PIAS3-Smurf2 sumoylation pathway suppresses breast cancer organoid invasiveness","year":2017,"lang":"en","type":"article","venue":"Oncotarget","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research; Alberta Innovates","keywords":"SUMO protein; Ubiquitin ligase; Breast cancer; Cancer research; Metastasis; Cancer; Organoid; Ubiquitin; Medicine; Biology; Oncology; Internal medicine; Cell biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001385965,0.0003724402,0.0003102305,0.0002148962,0.0002249427,0.0003541231,0.0002212423,0.0002527073,0.001167397],"category_scores_gemma":[0.00007228859,0.0001639217,0.0003138204,0.0002073273,0.0002011967,0.0001445777,0.0002172845,0.0006863084,0.000431664],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00041158,"about_ca_system_score_gemma":0.0004269508,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001076749,"about_ca_topic_score_gemma":0.002078994,"domain_scores_codex":[0.999853,0.00002150763,0.00001215118,0.00002250011,0.00005071924,0.00004002038],"domain_scores_gemma":[0.999923,0.000005964685,0.00002467681,0.000009540924,0.000007723604,0.00002910677],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001543435,0.00003780872,0.0002722591,0.0000251126,0.000007990792,0.00004808391,0.00001090821,0.00008533687,0.9977474,0.00006200164,0.0001079847,0.001440671],"study_design_scores_gemma":[0.00002422753,0.000253292,0.005837507,0.000003207788,0.00001338029,0.0002385684,0.00005993364,0.001746533,0.9891666,0.00003443801,0.002617698,0.000004821223],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939477,0.001885099,0.001793975,0.0002252899,0.00003989249,0.00002311113,0.0003680531,0.0002042264,0.001512493],"genre_scores_gemma":[0.9960926,0.0005693226,0.0008376712,0.00004335401,0.000003597662,0.00002086689,0.0003601322,0.0000171893,0.002055289],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001167397,"threshold_uncertainty_score":0.003905296,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01394056415300088,"score_gpt":0.2677922270105471,"score_spread":0.2538516628575462,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}