{"id":"W2590300471","doi":"10.1182/blood.v126.23.4866.4866","title":"A Phase 1b, Open-Label, Dose Escalation and Expansion Study Evaluating the Safety and Efficacy of Entospletinib (GS-9973) with Vincristine and Dexamethasone in Adult Subjects with Relapsed or Refractory Acute Lymphoid Leukemia (ALL)","year":2015,"lang":"en","type":"article","venue":"Blood","topic":"Acute Lymphoblastic Leukemia research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Syk; Leukemia; Cancer research; Medicine; B cell; Immunology; Bone marrow; Stem cell; Pharmacology; Internal medicine; Tyrosine kinase; Biology; Receptor; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001219749,0.001289304,0.001776424,0.0005141655,0.0004365422,0.0009923466,0.0009836836,0.001333184,0.004675934],"category_scores_gemma":[0.000570524,0.0005260567,0.0008629728,0.0004472707,0.0009511626,0.00105538,0.000376314,0.003491289,0.001319229],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001035545,"about_ca_system_score_gemma":0.001168805,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006490598,"about_ca_topic_score_gemma":0.00192201,"domain_scores_codex":[0.9996191,0.0001446883,0.00001942449,0.00008814559,0.0000389754,0.000089635],"domain_scores_gemma":[0.9994587,0.00005820046,0.00008399381,0.00007236405,0.00003780508,0.0002889085],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5827061,0.1793003,0.004068374,0.000902576,0.001017192,0.0003179619,0.0003445032,0.002640823,0.1081523,0.0004187998,0.00387633,0.1162548],"study_design_scores_gemma":[0.3630442,0.6181453,0.009027796,0.00002889583,0.0002416803,0.0003123028,0.00008209141,0.0009537244,0.005226998,0.0002258381,0.002678339,0.00003285597],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945821,0.001064654,0.0004698563,0.0002564247,0.00007504606,0.001709018,0.0009144496,0.00008595601,0.0008424401],"genre_scores_gemma":[0.9905213,0.0008706994,0.00134995,0.0005342984,0.00007371121,0.001971245,0.001782311,0.00002814152,0.002868327],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004675934,"threshold_uncertainty_score":0.01564252,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05963480540907737,"score_gpt":0.3749456455827471,"score_spread":0.3153108401736697,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}