{"id":"W2590351842","doi":"10.1186/s12916-017-0800-1","title":"Developmental pathways to adiposity begin before birth and are influenced by genotype, prenatal environment and epigenome","year":2017,"lang":"en","type":"article","venue":"BMC Medicine","topic":"Birth, Development, and Health","field":"Medicine","cited_by":114,"is_retracted":false,"has_abstract":true,"ca_institutions":"Child and Family Research Institute; McGill University; Douglas Mental Health University Institute; University of British Columbia","funders":"Medical Research Council; Ludmer Centre for Neuroinformatics and Mental Health; National University Health System; Singapore Eye Research Institute; Agency for Science, Technology and Research; National Research Foundation Singapore; National Medical Research Council; National Research Foundation; British Heart Foundation; National University of Singapore; National Institute for Health Research Southampton Biomedical Research Centre; European Commission; McGill University; University of Southampton; Singapore Institute for Clinical Sciences; National Institute for Health and Care Research; University Hospital Southampton NHS Foundation Trust","keywords":"Epigenome; Offspring; Medicine; Birth weight; Pregnancy; Obesity; DNA methylation; Physiology; Fetus; Bioinformatics; Genetics; Endocrinology; Biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004102743,0.0002676175,0.0005034702,0.0001069855,0.0005320247,0.00002493283,0.0001570239,0.0001220636,0.0001438845],"category_scores_gemma":[0.0001841378,0.0002052608,0.00002006112,0.00004492409,0.0003472563,0.000102548,0.0002241685,0.0002085272,0.00004465917],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000162098,"about_ca_system_score_gemma":0.0002084543,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002126116,"about_ca_topic_score_gemma":0.0002920457,"domain_scores_codex":[0.9982763,0.00002578498,0.00036472,0.0005261758,0.0003876141,0.0004194187],"domain_scores_gemma":[0.9986214,0.00003021539,0.0001950578,0.0003544694,0.00003512235,0.0007637278],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002525223,0.00007513102,0.9696565,0.0006206082,0.00006771609,0.00006049301,0.004902902,2.251507e-7,0.008178407,0.0007866365,0.001448421,0.01395046],"study_design_scores_gemma":[0.002813562,0.0006001043,0.9859771,0.0004346421,0.00005368194,0.00009293106,0.0004327936,0.00001159569,0.0009715139,0.0004116182,0.007991191,0.0002092884],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929497,0.001736092,0.0002374792,0.002697704,0.000103787,0.0008164442,0.00005290448,0.00004316576,0.0013627],"genre_scores_gemma":[0.9861112,0.005493497,0.0055258,0.002102059,0.0002108358,0.0000424625,0.00005608787,0.00003052063,0.0004275074],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0163206,"threshold_uncertainty_score":0.8370294,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02643581579194512,"score_gpt":0.2635238771434174,"score_spread":0.2370880613514723,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}