{"id":"W2590351842","doi":"10.1186/s12916-017-0800-1","title":"Developmental pathways to adiposity begin before birth and are influenced by genotype, prenatal environment and epigenome","year":2017,"lang":"en","type":"article","venue":"BMC Medicine","topic":"Birth, Development, and Health","field":"Medicine","cited_by":114,"is_retracted":false,"has_abstract":true,"ca_institutions":"Child and Family Research Institute; McGill University; Douglas Mental Health University Institute; University of British Columbia","funders":"Medical Research Council; Ludmer Centre for Neuroinformatics and Mental Health; National University Health System; Singapore Eye Research Institute; Agency for Science, Technology and Research; National Research Foundation Singapore; National Medical Research Council; National Research Foundation; British Heart Foundation; National University of Singapore; National Institute for Health Research Southampton Biomedical Research Centre; European Commission; McGill University; University of Southampton; Singapore Institute for Clinical Sciences; National Institute for Health and Care Research; University Hospital Southampton NHS Foundation Trust","keywords":"Epigenome; Offspring; Medicine; Birth weight; Pregnancy; Obesity; DNA methylation; Physiology; Fetus; Bioinformatics; Genetics; Endocrinology; Biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003422107,0.0002945115,0.0002551251,0.0003685055,0.0002338775,0.0004110897,0.0001808311,0.0002054505,0.002049349],"category_scores_gemma":[0.0009977615,0.0002067786,0.0003702657,0.00053791,0.0003456505,0.000218272,0.0004572451,0.000375471,0.0002030905],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002677551,"about_ca_system_score_gemma":0.0004235758,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004483994,"about_ca_topic_score_gemma":0.006388266,"domain_scores_codex":[0.9997224,0.00007271851,0.00001283175,0.00009305577,0.00004626887,0.00005262622],"domain_scores_gemma":[0.9993573,0.0001623455,0.0002677892,0.00005809186,0.0000688135,0.00008561382],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000754836,0.00005579452,0.9070677,0.0001347327,0.0003387668,0.0005027486,0.0005229895,0.0004321869,0.06476692,0.0008209992,0.0003411146,0.02426107],"study_design_scores_gemma":[0.000002531614,0.00003864168,0.9973612,0.00001511101,0.00003476151,0.0001269996,0.00005355122,0.00008492591,0.001538172,0.0001857216,0.0005548602,0.000003454012],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903609,0.002310491,0.004023822,0.0001389792,0.0000152545,0.00001994604,0.001630372,0.00004905232,0.001451337],"genre_scores_gemma":[0.9936327,0.001564906,0.003119146,0.00006564892,0.000006197359,0.00003783068,0.0007147852,0.00002386638,0.0008349959],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004483994,"threshold_uncertainty_score":0.008915782,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02643581579194512,"score_gpt":0.2635238771434174,"score_spread":0.2370880613514723,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}