{"id":"W2590449131","doi":"10.1016/j.pupt.2017.02.004","title":"Methacholine challenge tests to demonstrate therapeutic equivalence of terbutaline sulfate via different Turbuhaler ® devices in patients with mild to moderate asthma: Appraisal of a four-way crossover design","year":2017,"lang":"en","type":"article","venue":"Pulmonary Pharmacology & Therapeutics","topic":"Asthma and respiratory diseases","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval; McMaster University","funders":"AstraZeneca","keywords":"Asthma; Crossover study; Terbutaline; Methacholine; Medicine; Crossover; Equivalence (formal languages); Pharmacology; Anesthesia; Mathematics; Computer science; Internal medicine; Alternative medicine; Artificial intelligence; Respiratory disease; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.03258245,0.003514553,0.009302548,0.001248001,0.00143452,0.002215152,0.002783584,0.004347647,0.00321774],"category_scores_gemma":[0.02469511,0.001861281,0.004721001,0.001172347,0.004583089,0.003687127,0.001210878,0.004979942,0.0008116713],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001748001,"about_ca_system_score_gemma":0.001711994,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008710108,"about_ca_topic_score_gemma":0.001112552,"domain_scores_codex":[0.9574078,0.03155368,0.00364059,0.003117691,0.002998094,0.001282168],"domain_scores_gemma":[0.9693485,0.01663997,0.0048529,0.004358558,0.002777937,0.002022175],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.9600209,0.02004199,0.002105254,0.0003657013,0.001421101,0.00002782747,0.0002720099,0.0003209899,0.004448697,0.0001542732,0.0001518512,0.01066944],"study_design_scores_gemma":[0.3115112,0.6751119,0.008397468,0.00004154359,0.001274882,0.00003852604,0.0001284793,0.0008834127,0.001847378,0.0001985146,0.0005004267,0.00006627121],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9784846,0.003466411,0.004654283,0.0003777804,0.001189571,0.0102797,0.0004767345,0.0001210622,0.0009498454],"genre_scores_gemma":[0.9836341,0.001057324,0.007228056,0.0004761792,0.0007278517,0.005721294,0.000307741,0.00003935321,0.0008080784],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03258245,"threshold_uncertainty_score":0.1723145,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06386305407375913,"score_gpt":0.3562320054833732,"score_spread":0.2923689514096141,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}