{"id":"W2590526873","doi":"","title":"The combined effect of drusen component amyloid beta and oxidative stress on polarized retinal pigment epithelium","year":2016,"lang":"en","type":"article","venue":"","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"Drusen; Retinal pigment epithelium; Oxidative stress; Pigment; Retinal; Chemistry; Amyloid (mycology); Cell biology; Biophysics; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001742962,0.0002504082,0.0002774836,0.00019211,0.0002815212,0.0003705148,0.0001275621,0.0003710954,0.001443732],"category_scores_gemma":[0.0001621311,0.0002087798,0.0003338961,0.0001412976,0.0001858811,0.0004483214,0.0002411983,0.0006212276,0.000181605],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001800577,"about_ca_system_score_gemma":0.0003326322,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008125245,"about_ca_topic_score_gemma":0.001375286,"domain_scores_codex":[0.9998349,0.00004631907,0.00001024461,0.00001914846,0.00002841488,0.0000610086],"domain_scores_gemma":[0.9998627,0.00002817155,0.00001576115,0.00001706067,0.00002873223,0.00004756973],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00379194,0.000148989,0.00154575,0.0001141887,0.00003595446,0.0002688262,0.00007890591,0.00005706435,0.9886568,0.0001732405,0.0001192818,0.00500901],"study_design_scores_gemma":[0.0001528823,0.003089029,0.06167054,0.00002943741,0.0001674223,0.000873031,0.0009980864,0.0008570246,0.9281098,0.0003105345,0.003721032,0.00002118111],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967334,0.001887487,0.0002232015,0.0001102526,0.00005442778,0.000007834629,0.00006675242,0.000007455116,0.0009091988],"genre_scores_gemma":[0.9965576,0.001398657,0.0003352127,0.00006810159,0.00002330781,0.00001418277,0.00007360806,0.000004008446,0.001525419],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001443732,"threshold_uncertainty_score":0.004829824,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01398899698204515,"score_gpt":0.2894807631777646,"score_spread":0.2754917661957194,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}