{"id":"W2590621618","doi":"10.1080/15548627.2017.1290751","title":"New frontiers in the treatment of colorectal cancer: Autophagy and the unfolded protein response as promising targets","year":2017,"lang":"en","type":"review","venue":"Autophagy","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":155,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University of Manitoba","funders":"National Institute for Genetic Engineering and Biotechnology; Natural Sciences and Engineering Research Council of Canada; Mitacs","keywords":"Autophagy; Unfolded protein response; Biology; Colorectal cancer; Cancer; Malignancy; Cancer research; Disease; Bioinformatics; Gene; Genetics; Apoptosis; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0008676673,0.0006479776,0.002765887,0.0002440083,0.0002463925,0.00008027957,0.000544483,0.0003760693,0.0001138189],"category_scores_gemma":[0.0002242425,0.0003172817,0.0007133213,0.0002601442,0.0004831757,0.00008469584,0.00005033631,0.000362529,0.00001381844],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003466833,"about_ca_system_score_gemma":0.002646691,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009637433,"about_ca_topic_score_gemma":0.00002372948,"domain_scores_codex":[0.9966987,0.0009898244,0.0008251677,0.0005778737,0.0004411887,0.0004671843],"domain_scores_gemma":[0.9974855,0.0004391016,0.000806523,0.001037021,0.00005187933,0.0001799585],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.004273088,0.0002949445,0.000009956579,0.001696892,0.0009575908,0.0004614593,0.002275123,2.797426e-7,0.00002724947,0.0003026045,0.0005569125,0.9891439],"study_design_scores_gemma":[0.009874468,0.001400951,0.000802509,0.006393027,0.002344461,0.0002016973,0.0001021732,0.00003865246,0.0009833751,0.001152135,0.9763286,0.0003779513],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.02006962,0.9718226,0.000009578167,0.0004999761,0.0003832843,0.00677469,0.00004498351,0.00004433407,0.0003509583],"genre_scores_gemma":[0.002819277,0.9915296,0.0003572495,0.0001132785,0.0002676623,0.001395479,0.00003716767,0.00007891987,0.003401346],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.988766,"threshold_uncertainty_score":0.9999279,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04179167769608115,"score_gpt":0.3749443467288048,"score_spread":0.3331526690327236,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}