{"id":"W2590833518","doi":"10.1182/blood.v110.11.3385.3385","title":"High Expression of MDR1 and BCRP1 in Leukemic Stem Cells Correlates with Reversible Drug Resistance Ex Vivo and Predicts Failure of Remission Induction Chemotherapy in Patients with Acute Myeloid Leukemia.","year":2007,"lang":"en","type":"article","venue":"Blood","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Terry Fox Research Institute","funders":"","keywords":"Daunorubicin; Myeloid leukemia; CD38; Ex vivo; CD34; Leukemia; ATP-binding cassette transporter; Stem cell; Chemotherapy; Cancer research; Bone marrow; Pharmacology; Biology; In vivo; Immunology; Medicine; Internal medicine; Transporter; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002112878,0.0001760089,0.0002869624,0.0004113923,0.0001352258,0.0002992298,0.0001066918,0.0002536154,0.001463203],"category_scores_gemma":[0.0005552838,0.0001181409,0.00008921627,0.0002085507,0.0001994549,0.0001463375,0.0001594425,0.0003660643,0.0003381509],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001553638,"about_ca_system_score_gemma":0.00007182197,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003123352,"about_ca_topic_score_gemma":0.0003380063,"domain_scores_codex":[0.9997864,0.00004300937,0.00002340195,0.00004631241,0.00006020177,0.00004065038],"domain_scores_gemma":[0.9996725,0.00009945592,0.00008607275,0.00002609488,0.00003069853,0.00008518095],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002071602,0.0002749157,0.3338314,0.00005855281,0.0000571418,0.0005561013,0.0001756238,0.0002098019,0.6473621,0.00006840427,0.0002950619,0.01503943],"study_design_scores_gemma":[0.00006407637,0.002190666,0.9396091,0.000007399439,0.00004776323,0.003785716,0.0001113627,0.0008122422,0.0522149,0.00005357014,0.00109688,0.00000632715],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989703,0.0003618799,0.0001425328,0.00001928314,0.000002683165,0.000009914356,0.0001022654,0.00001053232,0.0003805984],"genre_scores_gemma":[0.9989842,0.0001008008,0.0001902387,0.00002844379,0.000006801206,0.00001361272,0.0004084627,0.000002918695,0.0002646558],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001463203,"threshold_uncertainty_score":0.004894912,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.002824155945140957,"score_gpt":0.1748007411230027,"score_spread":0.1719765851778618,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}