{"id":"W2590840427","doi":"10.1182/blood.v120.21.3461.3461","title":"Systemic Ceramide Accumulation Causes Dysregulated Hematopoiesis","year":2012,"lang":"en","type":"article","venue":"Blood","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; University of Toronto","funders":"","keywords":"Spleen; Bone marrow; Haematopoiesis; Biology; Ceramide; Lymphopoiesis; Peripheral blood cell; Leukocytosis; Lymph; CD8; Internal medicine; Endocrinology; Immunology; Molecular biology; Pathology; Stem cell; Immune system; Cell biology; Medicine; Biochemistry; Apoptosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001704424,0.000890912,0.0006429508,0.0007025101,0.0001917415,0.0003227647,0.0002384773,0.0007569661,0.003196887],"category_scores_gemma":[0.000146744,0.000290395,0.0003033925,0.0002651618,0.0005419467,0.0002540384,0.0004563679,0.001103953,0.0009116217],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002767766,"about_ca_system_score_gemma":0.0001699432,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002010621,"about_ca_topic_score_gemma":0.0002163482,"domain_scores_codex":[0.9996904,0.00004419609,0.00003095762,0.00008441187,0.00008150477,0.00006851369],"domain_scores_gemma":[0.9996607,0.00005549831,0.00009772338,0.00003835394,0.00001691214,0.0001307425],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002225585,0.00004525554,0.0001715878,0.00003113748,0.000004786221,0.0005369856,0.00001379845,0.00005610838,0.9979078,0.00006797394,0.00006080472,0.0008812136],"study_design_scores_gemma":[0.0001108447,0.001304789,0.007908669,0.0000180167,0.00003651892,0.003646177,0.00005984126,0.001239823,0.9831846,0.0002098068,0.002265377,0.00001550712],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929015,0.00125533,0.002576164,0.0001193262,0.00005249185,0.00005721263,0.0007611992,0.0003822411,0.001894461],"genre_scores_gemma":[0.99274,0.0006986986,0.00140156,0.0001070786,0.00003299825,0.00008253336,0.000786031,0.00009179363,0.004059307],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003196887,"threshold_uncertainty_score":0.01069468,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01990988500290313,"score_gpt":0.2649460539043694,"score_spread":0.2450361689014662,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}