{"id":"W2590842281","doi":"10.1200/jco.2014.32.4_suppl.7","title":"Results from a phase 3, randomized, double-blind, multicenter, placebo-controlled trial of orteronel (TAK-700) plus prednisone in patients with metastatic castration-resistant prostate cancer (mCRPC) that has progressed during or following docetaxel-based therapy (ELM-PC 5 trial).","year":2014,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"","keywords":"Medicine; Clinical endpoint; Prednisone; Abiraterone acetate; Placebo; Prostate cancer; Internal medicine; Adverse effect; Population; Ketoconazole; Urology; Randomized controlled trial; Cancer; Oncology; Gastroenterology; Androgen deprivation therapy; Dermatology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.007476345,0.0004111599,0.005301778,0.0003846537,0.0001079964,0.00006498039,0.0002552988,0.0002869745,0.00006996055],"category_scores_gemma":[0.00351509,0.0002113292,0.0009905146,0.0002862827,0.0004473528,0.0002756178,0.00003180972,0.0009042467,0.000001430497],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004432751,"about_ca_system_score_gemma":0.005135678,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003149679,"about_ca_topic_score_gemma":0.0005116258,"domain_scores_codex":[0.9902145,0.002398248,0.005071103,0.0005091401,0.00126563,0.0005413255],"domain_scores_gemma":[0.9867104,0.006931046,0.004854114,0.0003802148,0.0006809968,0.0004432753],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9664077,0.01934881,0.001744159,0.00008338091,0.004179155,0.0005049826,0.0007098384,0.0002588829,0.0001718931,7.111342e-7,0.00002444402,0.006566108],"study_design_scores_gemma":[0.9351259,0.05839195,0.001278226,0.0007797012,0.001968179,0.000002418328,0.0001123586,0.001369191,0.0006187609,0.00001234257,0.0001489913,0.0001919809],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9800764,0.0005679585,0.00008251451,0.00199653,0.001178087,0.01596514,0.00007474364,0.00001492291,0.00004370396],"genre_scores_gemma":[0.9962488,0.0004425348,0.0013854,0.0001198483,0.0004942389,0.0009872519,0.0000845598,0.00004841667,0.0001889188],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03904314,"threshold_uncertainty_score":0.9110472,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1853352785079801,"score_gpt":0.4686484202466603,"score_spread":0.2833131417386802,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}