{"id":"W2590946443","doi":"10.1093/annonc/mdx074","title":"Carbon dating cancer: defining the chronology of metastatic progression in colorectal cancer","year":2017,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute of Cancer Research","funders":"Associazione Italiana per la Ricerca sul Cancro; National Institute for Health and Care Research; European Commission; Royal Marsden NHS Foundation Trust; National Cancer Institute; National Institutes of Health; Cancer Research UK; Wellcome Trust; Pancreatic Cancer UK","keywords":"Medicine; Primary tumor; Cancer; Thyroid cancer; Colorectal cancer; Metastasis; Pathology; Somatic evolution in cancer; Oncology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003320358,0.0000956826,0.0002719675,0.0000354486,0.00007500108,0.000007061039,0.0003281703,0.0001094036,0.00001520407],"category_scores_gemma":[0.0003824744,0.00007561862,0.00005480748,0.00003541485,0.0003075867,0.000002961679,0.0002330158,0.00009622178,2.990226e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002031387,"about_ca_system_score_gemma":0.0004861495,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003125181,"about_ca_topic_score_gemma":0.007684523,"domain_scores_codex":[0.9991601,0.00007105586,0.0002894215,0.0001970869,0.00006452882,0.0002177941],"domain_scores_gemma":[0.9989736,0.00008603578,0.0005150106,0.0002783682,0.0001174964,0.00002946791],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005815136,0.0002518529,0.1975087,0.00009107636,0.0002216574,0.00001364858,0.0004419964,0.001093544,0.4559459,0.001033637,0.001344841,0.3414716],"study_design_scores_gemma":[0.001544387,0.002459754,0.09760516,0.0001272043,0.00006038671,0.000009483408,0.0002300339,0.0006407662,0.8783402,0.0003585246,0.01842073,0.0002033704],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.987732,0.007598607,0.000005312563,0.001647881,0.0002721352,0.0001679193,0.00005184021,0.000001555745,0.002522778],"genre_scores_gemma":[0.9938499,0.005517486,0.0002220869,0.0001896619,0.00008925659,0.0000928439,0.0000144723,0.000011101,0.00001323601],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4223943,"threshold_uncertainty_score":0.4724359,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04982768630205411,"score_gpt":0.4108058589485773,"score_spread":0.3609781726465232,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}