{"id":"W2590946443","doi":"10.1093/annonc/mdx074","title":"Carbon dating cancer: defining the chronology of metastatic progression in colorectal cancer","year":2017,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute of Cancer Research","funders":"Associazione Italiana per la Ricerca sul Cancro; National Institute for Health and Care Research; European Commission; Royal Marsden NHS Foundation Trust; National Cancer Institute; National Institutes of Health; Cancer Research UK; Wellcome Trust; Pancreatic Cancer UK","keywords":"Medicine; Primary tumor; Cancer; Thyroid cancer; Colorectal cancer; Metastasis; Pathology; Somatic evolution in cancer; Oncology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001543042,0.0003435292,0.0003923848,0.003104721,0.0007272925,0.002975076,0.0005797584,0.0009225189,0.002565503],"category_scores_gemma":[0.004645335,0.0003031835,0.0001795314,0.003032651,0.0007930207,0.001885482,0.0008428161,0.001180062,0.0005790375],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001478448,"about_ca_system_score_gemma":0.001325568,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005937384,"about_ca_topic_score_gemma":0.01180401,"domain_scores_codex":[0.9994863,0.0001418992,0.000041541,0.0001084735,0.0001500147,0.00007164686],"domain_scores_gemma":[0.9978343,0.0004812597,0.0005834327,0.0001535515,0.0006597825,0.0002876771],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002088774,0.0001320855,0.4751614,0.001714536,0.0002077431,0.001316861,0.002273024,0.003748107,0.05129249,0.05174237,0.01647417,0.3938484],"study_design_scores_gemma":[0.00006204454,0.0008425236,0.6105277,0.001213266,0.0003509682,0.007531306,0.003432242,0.005811008,0.04187909,0.02755438,0.3006328,0.0001625653],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6477612,0.26634,0.02481933,0.009887921,0.0021955,0.0001363427,0.003761222,0.0005313978,0.04456712],"genre_scores_gemma":[0.9427103,0.04062129,0.009484636,0.0006831025,0.0007631202,0.00004332678,0.0009118741,0.0001519615,0.004630271],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005937384,"threshold_uncertainty_score":0.01180565,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04982768630205411,"score_gpt":0.4108058589485773,"score_spread":0.3609781726465232,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}