{"id":"W2590949011","doi":"10.1007/s13311-017-0514-2","title":"Targeting Epigenetic Pathways in the Treatment of Pediatric Diffuse (High Grade) Gliomas","year":2017,"lang":"en","type":"review","venue":"Neurotherapeutics","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":false,"ca_institutions":"Stollery Children's Hospital; University of Alberta; Research Institute in Oncology and Hematology; University of Manitoba; CancerCare Manitoba","funders":"Kids With Cancer Society; University of Alberta; Alberta Cancer Foundation; St. Baldrick's Foundation; Melanoma Research Alliance","keywords":"Epigenetics; Medicine; Temozolomide; Histone H3; Histone; Cancer research; Receptor tyrosine kinase; Oncology; Bioinformatics; Biology; Internal medicine; Glioma; Gene; Receptor; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001425312,0.0005948241,0.001909184,0.0003717214,0.0001135527,0.00004799862,0.0003589258,0.0002663156,0.00002115323],"category_scores_gemma":[0.000030581,0.0003282112,0.0006951316,0.000344644,0.0000761175,0.00002120272,0.00001838643,0.0002318377,0.00003109621],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000129971,"about_ca_system_score_gemma":0.00020432,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006234225,"about_ca_topic_score_gemma":0.00001061437,"domain_scores_codex":[0.9976157,0.0002932821,0.0008069342,0.0004796029,0.0004053743,0.0003990923],"domain_scores_gemma":[0.9975476,0.0004787965,0.0006305808,0.001210399,0.0000441061,0.00008846766],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001444215,0.006092855,0.002084317,0.003570873,0.0003291729,0.0009353468,0.0004866585,0.000001324938,0.000006862383,0.0001020305,0.00003857118,0.9863375],"study_design_scores_gemma":[0.002634139,0.001833203,0.001282984,0.0009407328,0.004845325,0.00009163106,0.00001713342,0.000007977327,0.00002733078,0.00004257777,0.9880081,0.0002688472],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.005579102,0.9912125,0.000001702734,0.00009944085,0.0002814734,0.002621992,0.00006985442,0.0000247253,0.0001091462],"genre_scores_gemma":[0.006022773,0.9925971,0.00007830135,0.00008632418,0.0005064853,0.0004927039,0.00007523102,0.0001092064,0.00003189018],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9879695,"threshold_uncertainty_score":0.999917,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1675969174301123,"score_gpt":0.3712586353660016,"score_spread":0.2036617179358894,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}