{"id":"W2591056031","doi":"10.1182/blood.v128.22.2054.2054","title":"Safety and Efficacy of Venetoclax and Obinutuzumab in Patients with Previously Untreated Chronic Lymphocytic Leukemia (CLL) and Coexisting Medical Conditions: Final Results of the Run-in Phase of the Randomized CLL14 Trial (BO25323)","year":2016,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen Elizabeth II Health Sciences Centre","funders":"","keywords":"Venetoclax; Obinutuzumab; Chronic lymphocytic leukemia; Medicine; Internal medicine; IGHV@; Oncology; Randomized controlled trial; Leukemia; Bendamustine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004485139,0.0008651081,0.002148874,0.0002917158,0.0004772908,0.001177109,0.0006726056,0.001175899,0.001999278],"category_scores_gemma":[0.002298346,0.0004634745,0.001520814,0.0003446299,0.0007882073,0.0007279162,0.0004679332,0.002103445,0.0003271492],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000756749,"about_ca_system_score_gemma":0.001464952,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006011898,"about_ca_topic_score_gemma":0.00146223,"domain_scores_codex":[0.9981499,0.001318947,0.00007837548,0.0001535722,0.0001044552,0.0001947501],"domain_scores_gemma":[0.9983152,0.000458422,0.0004343349,0.0001794629,0.0001015469,0.0005109791],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9325272,0.01431807,0.008118244,0.0003263422,0.001058367,0.00008274821,0.0001195535,0.0005787622,0.006794395,0.0001035572,0.0007617541,0.03521108],"study_design_scores_gemma":[0.7004786,0.2758674,0.0179922,0.00004706612,0.0009659824,0.0001809933,0.00004838017,0.0006290643,0.002028023,0.0001684182,0.001559138,0.00003484447],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943773,0.002912938,0.0003143079,0.0002235446,0.00008472086,0.0008400214,0.0004464433,0.00003544797,0.0007651436],"genre_scores_gemma":[0.9959075,0.0005965602,0.0007407031,0.000281471,0.0001663187,0.000957521,0.0007313741,0.000009537001,0.0006090777],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004485139,"threshold_uncertainty_score":0.02372003,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01486833435341819,"score_gpt":0.2885356770874252,"score_spread":0.273667342734007,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}