{"id":"W2591056031","doi":"10.1182/blood.v128.22.2054.2054","title":"Safety and Efficacy of Venetoclax and Obinutuzumab in Patients with Previously Untreated Chronic Lymphocytic Leukemia (CLL) and Coexisting Medical Conditions: Final Results of the Run-in Phase of the Randomized CLL14 Trial (BO25323)","year":2016,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen Elizabeth II Health Sciences Centre","funders":"","keywords":"Venetoclax; Obinutuzumab; Chronic lymphocytic leukemia; Medicine; Internal medicine; IGHV@; Oncology; Randomized controlled trial; Leukemia; Bendamustine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001339448,0.0001867476,0.0009235234,0.0001154162,0.00005105045,0.000005800843,0.0001688957,0.0001527606,0.00001827333],"category_scores_gemma":[0.004725921,0.00008672253,0.00007736868,0.000345752,0.001409134,0.00004810968,0.0001679406,0.0001763176,2.46927e-7],"about_ca_system_candidate":true,"about_ca_system_consensus":true,"about_ca_system_score_codex":0.008435158,"about_ca_system_score_gemma":0.02115409,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001853564,"about_ca_topic_score_gemma":0.0003668368,"domain_scores_codex":[0.9971726,0.000491142,0.00101547,0.0003260866,0.0006974377,0.0002972548],"domain_scores_gemma":[0.9964854,0.002397654,0.0004351818,0.0004412621,0.000122454,0.0001180826],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9869746,0.0006607055,0.004827221,0.0007747168,0.0003834863,0.000040923,0.001090601,0.00005026067,0.0007728393,0.0001412599,0.00002249297,0.004260921],"study_design_scores_gemma":[0.9734533,0.001308313,0.01545744,0.003925385,0.0003414549,0.00006115726,0.00002634126,0.002886943,0.002402024,0.00003515126,0.000009285131,0.00009313425],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961768,0.0007449983,0.000002367607,0.00006342315,0.00003235585,0.002792021,0.00007628073,0.000007373131,0.0001043286],"genre_scores_gemma":[0.999441,0.0003544156,0.00002192876,0.00001268,0.00003574434,0.00003908664,0.00001399631,0.00001726182,0.00006385012],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0135212,"threshold_uncertainty_score":0.9953713,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01486833435341819,"score_gpt":0.2885356770874252,"score_spread":0.273667342734007,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}