{"id":"W2591120917","doi":"10.1182/blood.v118.21.258.258","title":"Adding Mercaptopurine and Methotrexate to Alternate Week ATRA Maintenance Therapy Does Not Improve the Outcome for Adults with Acute Promyelocytic Leukemia (APL) in First Remission: Results From North American Leukemia Intergroup Trial C9710","year":2011,"lang":"en","type":"article","venue":"Blood","topic":"Retinoids in leukemia and cellular processes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"","keywords":"Medicine; Maintenance therapy; Mercaptopurine; Cytarabine; Acute promyelocytic leukemia; Internal medicine; Hazard ratio; Randomization; Randomized controlled trial; Clinical endpoint; Methotrexate; Leukemia; Cumulative incidence; Gastroenterology; Surgery; Chemotherapy; Confidence interval; Transplantation; Retinoic acid","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003508125,0.0003942739,0.0004373822,0.00005567447,0.0001351398,0.00005517834,0.0005550952,0.0001162272,0.000003961564],"category_scores_gemma":[0.0002550827,0.000222896,0.0001061742,0.0001973421,0.0001981826,0.00001701619,0.0001840509,0.0002475328,0.000001629558],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008899631,"about_ca_system_score_gemma":0.0002250257,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00116803,"about_ca_topic_score_gemma":0.00162592,"domain_scores_codex":[0.9977105,0.00008555193,0.0005943963,0.0009278508,0.0001906057,0.0004911001],"domain_scores_gemma":[0.9985984,0.0001024179,0.0003598641,0.0006439904,0.0001345395,0.0001607948],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.3674072,0.0006951093,0.01789629,0.000257216,0.001729217,0.0003119083,0.009057173,0.00004960282,0.5489985,0.00005214013,0.0002938846,0.05325171],"study_design_scores_gemma":[0.05281057,0.005161519,0.004698192,0.000190585,0.0001950193,0.00004173191,0.0005394443,0.0001464848,0.9320462,0.00007028201,0.003385012,0.000714893],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971735,0.0001547918,0.0005121612,0.0002073839,0.000178302,0.001317962,0.00025632,0.00002587473,0.0001736556],"genre_scores_gemma":[0.989749,0.0008303974,0.007630708,0.000309569,0.000381394,0.0003881278,0.0001250378,0.000060377,0.0005254045],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3830477,"threshold_uncertainty_score":0.9089434,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01603579901046855,"score_gpt":0.2453781777968862,"score_spread":0.2293423787864176,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}