{"id":"W2591120917","doi":"10.1182/blood.v118.21.258.258","title":"Adding Mercaptopurine and Methotrexate to Alternate Week ATRA Maintenance Therapy Does Not Improve the Outcome for Adults with Acute Promyelocytic Leukemia (APL) in First Remission: Results From North American Leukemia Intergroup Trial C9710","year":2011,"lang":"en","type":"article","venue":"Blood","topic":"Retinoids in leukemia and cellular processes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"","keywords":"Medicine; Maintenance therapy; Mercaptopurine; Cytarabine; Acute promyelocytic leukemia; Internal medicine; Hazard ratio; Randomization; Randomized controlled trial; Clinical endpoint; Methotrexate; Leukemia; Cumulative incidence; Gastroenterology; Surgery; Chemotherapy; Confidence interval; Transplantation; Retinoic acid","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003111451,0.0009403697,0.00222213,0.000296251,0.0004224749,0.0008894569,0.001031812,0.001654824,0.002981604],"category_scores_gemma":[0.001315183,0.0003348636,0.001960725,0.0004183053,0.0008163853,0.0006494998,0.0003912038,0.00316022,0.0006069587],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006673724,"about_ca_system_score_gemma":0.00143851,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001221448,"about_ca_topic_score_gemma":0.003068174,"domain_scores_codex":[0.999177,0.0005205595,0.00004670737,0.00009873533,0.00005816131,0.00009886018],"domain_scores_gemma":[0.9983896,0.0004424793,0.0003676554,0.0001512729,0.00008493366,0.0005641048],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9553388,0.008518182,0.003261621,0.0004552398,0.001513669,0.00006747916,0.00006183897,0.0003384984,0.00372816,0.0001189258,0.002076326,0.02452141],"study_design_scores_gemma":[0.8627395,0.1275932,0.006635305,0.00005681953,0.0009189214,0.00007660172,0.00002676948,0.0003489332,0.0005712197,0.0001066018,0.0009119055,0.00001422188],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911163,0.004366694,0.0002212009,0.0008324238,0.0002716768,0.000844951,0.0009669482,0.00006017647,0.001319691],"genre_scores_gemma":[0.9858919,0.003742837,0.0009217854,0.002091537,0.000500149,0.001792303,0.002923097,0.00002840895,0.002108025],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003111451,"threshold_uncertainty_score":0.01645511,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01603579901046855,"score_gpt":0.2453781777968862,"score_spread":0.2293423787864176,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}