{"id":"W2591383443","doi":"10.1186/s12885-017-3126-7","title":"Acetazolamide potentiates the anti-tumor potential of HDACi, MS-275, in neuroblastoma","year":2017,"lang":"en","type":"article","venue":"BMC Cancer","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University; University of Toronto; Hospital for Sick Children","funders":"Canadian Cancer Society Research Institute; Hospital for Sick Children; Rally Foundation","keywords":"Neuroblastoma; Cancer research; Homeobox protein NANOG; SOX2; Apoptosis; Histone deacetylase; Stem cell; Cyclin D1; Cancer stem cell; Biology; Cell culture; Cell cycle; Chemistry; Induced pluripotent stem cell; Cell biology; Embryonic stem cell; Biochemistry; Histone","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002283483,0.0001356225,0.0001705999,0.00005099858,0.0001967089,0.00005022542,0.000596472,0.00008263323,0.00006453996],"category_scores_gemma":[0.0001878292,0.0001070221,0.0001226607,0.00005679651,0.000316037,0.000008045819,0.0003177934,0.0001530553,0.00001503802],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002490521,"about_ca_system_score_gemma":0.0002181628,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001005703,"about_ca_topic_score_gemma":0.002820203,"domain_scores_codex":[0.998831,0.00008205947,0.0002243247,0.0003192043,0.0002320563,0.0003113455],"domain_scores_gemma":[0.9988595,0.0000109719,0.0001707134,0.0008087135,0.00009605238,0.00005401613],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001165795,0.00004860325,0.01463812,0.00003348189,0.00002009821,0.00001420029,0.00002638238,0.0006065064,0.9810224,0.00001197596,0.002944756,0.0005168879],"study_design_scores_gemma":[0.0007180923,0.00007728357,0.2102415,0.00003832727,0.00001274252,0.00001643413,0.0000293968,0.0003599213,0.7814959,0.00001242377,0.00685289,0.0001450435],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975471,0.0008314403,0.0001082494,0.0003294584,0.0003270177,0.0002172277,0.00003966116,0.000005591499,0.0005942003],"genre_scores_gemma":[0.9982138,0.0001819458,0.00006682396,0.00007274548,0.0003243034,0.00004553639,0.00000995742,0.00002612398,0.001058823],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1995265,"threshold_uncertainty_score":0.4364233,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01463323276471352,"score_gpt":0.3016498918583194,"score_spread":0.2870166590936059,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}