{"id":"W2591666318","doi":"10.1101/gad.292516.116","title":"ZMYM3 regulates BRCA1 localization at damaged chromatin to promote DNA repair","year":2017,"lang":"en","type":"article","venue":"Genes & Development","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":91,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"Division of Chemistry; Sun Yat-sen University Cancer Center; Cancer Prevention and Research Institute of Texas; Sun Yat-sen University; Welch Foundation; Canadian Institutes of Health Research; American Cancer Society; National Cancer Institute; National Institutes of Health; National Science Foundation","keywords":"Chromatin; Biology; DNA repair; Histone; Cell biology; DNA damage; Nucleosome; Chromatin remodeling; DNA; Genetics; ChIA-PET; Histone code; Molecular biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003230264,0.0002136491,0.0001603014,0.0000407406,0.0005735303,0.00006660982,0.0003872526,0.0001440407,0.00006702752],"category_scores_gemma":[0.0001049632,0.0002116338,0.00006873925,0.0000429497,0.0000399368,0.000006810243,0.0006961756,0.00003316409,0.0001825206],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008687703,"about_ca_system_score_gemma":0.0001365544,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009007641,"about_ca_topic_score_gemma":0.0001314205,"domain_scores_codex":[0.9985896,0.00003822031,0.0002848296,0.0005428458,0.0002203126,0.0003242416],"domain_scores_gemma":[0.9986343,0.000002497304,0.0001510148,0.0009602792,0.0001059253,0.0001460313],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003431058,0.0000355833,0.002004643,0.00003180863,0.00007037407,0.000009086181,0.0002602991,0.0000584566,0.9705676,0.00002159334,0.003455383,0.02345086],"study_design_scores_gemma":[0.0002372898,0.00007370682,0.01769701,0.00003048695,0.000008567406,0.00000955209,0.0000156157,0.0001207176,0.7727257,0.00002973303,0.2088092,0.00024248],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950656,0.0002252373,0.002888676,0.0001763508,0.0002763971,0.0004491197,0.000004294307,0.00008865769,0.0008256719],"genre_scores_gemma":[0.944266,0.00005367131,0.04586217,0.0003646146,0.0001593274,0.0001168152,0.0002155233,0.00005365608,0.008908205],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2053538,"threshold_uncertainty_score":0.8630174,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01100805138529474,"score_gpt":0.2435312340190003,"score_spread":0.2325231826337056,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}