{"id":"W2591669809","doi":"10.2196/jmir.6798","title":"Experience With Direct-to-Patient Recruitment for Enrollment Into a Clinical Trial in a Rare Disease: A Web-Based Study","year":2017,"lang":"en","type":"article","venue":"Journal of Medical Internet Research","topic":"Ethics in Clinical Research","field":"Medicine","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Joseph’s Healthcare Hamilton; McMaster University; University of Toronto; Mount Sinai Hospital","funders":"National Center for Advancing Translational Sciences; National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Heart, Lung, and Blood Institute; National Center for Research Resources; Vasculitis Clinical Research Consortium; Rare Diseases Clinical Research Network","keywords":"Disease; Medicine; Web application; Clinical trial; Rare disease; The Internet; Physical therapy; World Wide Web; Internal medicine; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","research_integrity"],"consensus_categories":["metaresearch"],"category_scores_codex":[0.05454778,0.0002241934,0.001060694,0.0006357968,0.0002036674,0.0002574946,0.002234713,0.0004102781,0.0005019499],"category_scores_gemma":[0.2174833,0.0001388202,0.0003592671,0.0002903655,0.00102543,0.0001444131,0.0009713569,0.005669933,0.00002026778],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006873889,"about_ca_system_score_gemma":0.006912888,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002266768,"about_ca_topic_score_gemma":0.001458981,"domain_scores_codex":[0.9828014,0.001656977,0.002367877,0.0007439268,0.01159902,0.0008308345],"domain_scores_gemma":[0.9747638,0.01739811,0.0005482301,0.00147413,0.002574519,0.003241231],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.641637,0.02289902,0.24875,0.0004526171,0.0004386653,0.009821809,0.005386103,0.00000749842,0.00003204975,0.0002773497,0.007726274,0.06257158],"study_design_scores_gemma":[0.4741002,0.2836066,0.1142752,0.01946487,0.0002081057,0.00006518769,0.008581414,0.006540363,0.000512266,0.001662452,0.09031721,0.0006662],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9491187,0.0001838381,0.0002469137,0.04336544,0.0006499838,0.005967609,0.000004148187,0.000009335583,0.000453966],"genre_scores_gemma":[0.9945745,0.0002145408,0.0011369,0.0007863377,0.0009361407,0.001459587,0.000002095347,0.00003812151,0.0008517093],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2607076,"threshold_uncertainty_score":0.998717,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.7374462592562504,"score_gpt":0.7051871209696952,"score_spread":0.03225913828655524,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}