{"id":"W2591672881","doi":"10.1097/md.0000000000006282","title":"High levels of virological failure with major genotypic resistance mutations in HIV-1-infected children after 5 years of care according to WHO-recommended 1st-line and 2nd-line antiretroviral regimens in the Central African Republic","year":2017,"lang":"en","type":"article","venue":"Medicine","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; Université du Québec à Montréal","funders":"","keywords":"Medicine; Viral load; Regimen; Genotyping; Drug resistance; Internal medicine; Antiretroviral therapy; Genotype; Virology; Human immunodeficiency virus (HIV); Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002935962,0.0001957496,0.0006291828,0.0002991606,0.0000701679,0.00001256615,0.0001766855,0.00007905865,0.00007072877],"category_scores_gemma":[0.0003204775,0.0001202338,0.00003496142,0.0003663246,0.0002329143,0.00008045491,0.00006664474,0.0002156327,0.000001396642],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008961422,"about_ca_system_score_gemma":0.00007698688,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003277099,"about_ca_topic_score_gemma":0.002626628,"domain_scores_codex":[0.9985049,0.00008914091,0.0004424562,0.000328669,0.0003181546,0.0003166999],"domain_scores_gemma":[0.9989926,0.0001085605,0.0002111408,0.0004878918,0.00009322069,0.0001065681],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00096863,0.0001635217,0.9871297,0.00007434354,0.00009765512,0.0001589606,0.00798763,0.00000522457,0.000425014,0.0001255137,0.0002914249,0.002572318],"study_design_scores_gemma":[0.006022124,0.0007664081,0.9898354,0.0005779234,0.0001432391,0.00002169038,0.00185409,0.000005774595,0.0004294649,0.00002872143,0.0002023768,0.0001128333],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9721158,0.0002120561,0.00004703988,0.02660898,0.00002862591,0.0007612429,0.00006470257,0.00001404679,0.0001475675],"genre_scores_gemma":[0.9970995,0.00002166777,0.002032501,0.0001950606,0.00007725477,0.00004787372,0.0001220052,0.00001693122,0.0003872003],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02641392,"threshold_uncertainty_score":0.4902992,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0136101558089547,"score_gpt":0.2613019732309859,"score_spread":0.2476918174220312,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}