{"id":"W2591672881","doi":"10.1097/md.0000000000006282","title":"High levels of virological failure with major genotypic resistance mutations in HIV-1-infected children after 5 years of care according to WHO-recommended 1st-line and 2nd-line antiretroviral regimens in the Central African Republic","year":2017,"lang":"en","type":"article","venue":"Medicine","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; Université du Québec à Montréal","funders":"","keywords":"Medicine; Viral load; Regimen; Genotyping; Drug resistance; Internal medicine; Antiretroviral therapy; Genotype; Virology; Human immunodeficiency virus (HIV); Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007787814,0.0002858235,0.0003414364,0.0007034584,0.0007521409,0.0006909295,0.0004106771,0.0006044533,0.000713009],"category_scores_gemma":[0.003569737,0.000327314,0.0003374928,0.0007111012,0.0006423199,0.0005381035,0.0004956175,0.0007279144,0.0001260021],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007538236,"about_ca_system_score_gemma":0.0006471484,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01256849,"about_ca_topic_score_gemma":0.01281847,"domain_scores_codex":[0.9991283,0.0002055461,0.00006287418,0.0001207595,0.0001772763,0.000305267],"domain_scores_gemma":[0.9982305,0.0002704223,0.0009405777,0.00007582564,0.0001778594,0.0003047377],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00006193904,0.00002040613,0.9985532,0.000005016414,0.00001114213,0.0001767864,0.0003162808,0.00002421153,0.0002036737,0.000009739914,0.00005506335,0.0005623997],"study_design_scores_gemma":[0.000003007797,0.0000850255,0.9991558,0.000004464962,0.000004237303,0.0003349547,0.0002599424,0.0000422586,0.00004944019,0.00000429139,0.00005444227,0.00000224961],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9997721,0.00009140878,0.000006918158,0.00001529196,0.000001340633,0.000002649909,0.00004205451,0.000001069457,0.00006720248],"genre_scores_gemma":[0.9998461,0.0000275115,0.00001280867,0.00001264358,0.000001954872,0.000002700112,0.00006371295,5.698901e-7,0.000032033],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01256849,"threshold_uncertainty_score":0.02499062,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0136101558089547,"score_gpt":0.2613019732309859,"score_spread":0.2476918174220312,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}