{"id":"W2591691881","doi":"10.1098/rspb.2016.2743","title":"Epistatic interactions influence terrestrial–marine functional shifts in cetacean rhodopsin","year":2017,"lang":"en","type":"article","venue":"Proceedings of the Royal Society B Biological Sciences","topic":"Photoreceptor and optogenetics research","field":"Neuroscience","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Rhodopsin; Biology; Epistasis; Opsin; Vertebrate; Evolutionary biology; Caenorhabditis elegans; Molecular evolution; Genetics; Phylogenetics; Retinal; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003477908,0.0004306205,0.0003058947,0.0005410794,0.0003411482,0.0004253555,0.0002623123,0.0003963998,0.001979378],"category_scores_gemma":[0.0008419337,0.0002010505,0.0003135791,0.0002915018,0.0003474134,0.0002172062,0.0007609889,0.0005071082,0.0002228041],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003756437,"about_ca_system_score_gemma":0.0003309017,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001373968,"about_ca_topic_score_gemma":0.003312432,"domain_scores_codex":[0.9995649,0.0001331422,0.0000459889,0.0001142798,0.0000881603,0.00005345643],"domain_scores_gemma":[0.9996675,0.0001226789,0.00008277391,0.00003031244,0.00003279288,0.00006394888],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000243028,0.00003738789,0.01090428,0.0000376292,0.0001025895,0.0003832494,0.00009927485,0.0004399558,0.9824806,0.0003582156,0.00006879021,0.004844992],"study_design_scores_gemma":[0.00007103247,0.0005866154,0.828406,0.00002952029,0.000644727,0.002794171,0.000857122,0.02100562,0.1394268,0.001757364,0.004281882,0.0001392035],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976459,0.0001624406,0.001241321,0.00004238882,0.000007133141,0.000006056249,0.00009801939,0.00003195745,0.0007647126],"genre_scores_gemma":[0.998966,0.00007256992,0.000583639,0.00005863199,0.000002665789,0.000005485395,0.00007126205,0.00002003776,0.000219812],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001979378,"threshold_uncertainty_score":0.006621659,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1153607302296841,"score_gpt":0.3461510485733638,"score_spread":0.2307903183436797,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}