{"id":"W2591728940","doi":"10.1101/gad.293134.116","title":"High constitutive activity of a broad panel of housekeeping and tissue-specific <i>cis</i>-regulatory elements depends on a subset of ETS proteins","year":2017,"lang":"en","type":"article","venue":"Genes & Development","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":87,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"European Research Council; Istituto Italiano di Tecnologia; Associazione Italiana per la Ricerca sul Cancro; Ministry of Health, British Columbia; Ministero della Salute","keywords":"Biology; Promoter; Enhancer; Housekeeping gene; Transcriptional regulation; Transcription factor; Chromatin; Housekeeping; Transcription (linguistics); Genetics; Regulation of gene expression; Gene; Cell biology; Gene expression","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002824179,0.0001339003,0.0002485551,0.00005832096,0.0001350364,0.00001226336,0.0002221543,0.00008509074,0.000006294516],"category_scores_gemma":[0.0000396184,0.0001269001,0.00003436939,0.00002930261,0.0002320196,0.000006965395,0.0002372678,0.00005501306,9.6478e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001966487,"about_ca_system_score_gemma":0.0002186003,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001016688,"about_ca_topic_score_gemma":0.00008892983,"domain_scores_codex":[0.998934,0.00003890084,0.0002742574,0.0002735323,0.0002597499,0.0002195504],"domain_scores_gemma":[0.9990857,0.000009743399,0.0003017169,0.0004094994,0.000119702,0.00007369198],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000251655,0.00008836791,0.007035458,0.00007973735,0.00009651476,0.000003597249,0.00008608869,0.000006659312,0.8978416,0.00007520424,0.00003517409,0.09439993],"study_design_scores_gemma":[0.000632595,0.0002167594,0.1392534,0.0000816199,0.000005308908,0.000002579655,0.00002551576,0.000002364164,0.8576234,0.00001091347,0.002039737,0.0001058484],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983182,0.0005222503,0.0005512999,0.00002522608,0.00004536502,0.0003374846,0.00003328833,0.000002982223,0.0001639223],"genre_scores_gemma":[0.9960823,0.0004502134,0.003261975,0.00001103356,0.00002163635,0.00002797844,0.00001835164,0.00001103094,0.0001154565],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1322179,"threshold_uncertainty_score":0.5174837,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03115417165168094,"score_gpt":0.2804861027369035,"score_spread":0.2493319310852226,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}