{"id":"W2591729184","doi":"10.15234/vpa.v15i4.352","title":"The Elusive Pathophysiology of Leber's Hereditary Optic Neuropathy","year":2016,"lang":"en","type":"article","venue":"DOAJ (DOAJ: Directory of Open Access Journals)","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"","keywords":"Penetrance; Leber's hereditary optic neuropathy; Optic neuropathy; Pathophysiology; Confusion; Mitochondrial disease; Optic nerve; Medicine; Disease; Atrophy; Pathology; Genetics; Ophthalmology; Biology; Mitochondrial DNA; Phenotype; Psychology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000556559,0.0004380084,0.0005873534,0.0006608167,0.0004463994,0.001431234,0.0005872071,0.001618725,0.0009525424],"category_scores_gemma":[0.0005699147,0.0001424764,0.0002151493,0.000242389,0.002555719,0.002383614,0.001068907,0.001495665,0.0004521654],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009446991,"about_ca_system_score_gemma":0.0008219182,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005823219,"about_ca_topic_score_gemma":0.000491983,"domain_scores_codex":[0.9997939,0.0000554437,0.00001927876,0.0000373446,0.00004664209,0.00004736272],"domain_scores_gemma":[0.9997334,0.00006088344,0.00006742641,0.0000176718,0.00003946376,0.00008115658],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.001471689,0.000367735,0.02508423,0.003075682,0.0001748412,0.04045483,0.002543072,0.001737213,0.2176772,0.3991351,0.03142581,0.2768526],"study_design_scores_gemma":[0.0003772428,0.001719823,0.08199589,0.002492097,0.000276911,0.07061577,0.007630677,0.00481274,0.05211911,0.4717072,0.3059291,0.0003235001],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":"theoretical_or_conceptual","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.2514948,0.6399034,0.008201584,0.0792118,0.003952804,0.00005451524,0.0003072195,0.0003477337,0.01652612],"genre_scores_gemma":[0.6979605,0.2830937,0.003700342,0.005664462,0.003680191,0.00006450266,0.0001362299,0.00002593978,0.005674178],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001618725,"threshold_uncertainty_score":0.006854355,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0927306066566923,"score_gpt":0.4631178045352435,"score_spread":0.3703871978785512,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}