{"id":"W2591759033","doi":"10.1128/aac.02665-16","title":"Integron-Associated DfrB4, a Previously Uncharacterized Member of the Trimethoprim-Resistant Dihydrofolate Reductase B Family, Is a Clinically Identified Emergent Source of Antibiotic Resistance","year":2017,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Université de Montréal; PROTEO; Centre in Green Chemistry and Catalysis","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Government of Canada","keywords":"Dihydrofolate reductase; Integron; Microbiology; Trimethoprim; Antibiotics; Biology; Antibiotic resistance; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009304615,0.0002420488,0.0002120669,0.0002909087,0.0001157336,0.0003312294,0.0001639456,0.0002822538,0.0009944191],"category_scores_gemma":[0.0002612526,0.0001060347,0.0001428475,0.0001464305,0.0001531432,0.00008775594,0.0001699003,0.0003339139,0.0002969285],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001912421,"about_ca_system_score_gemma":0.0001543819,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005753101,"about_ca_topic_score_gemma":0.0004401756,"domain_scores_codex":[0.9999053,0.00001645153,0.000005680174,0.00001836377,0.00003136826,0.00002278008],"domain_scores_gemma":[0.9998666,0.00002312175,0.00005519328,0.000009986595,0.00001633171,0.00002872643],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008634965,0.00002889244,0.00474854,0.00002296507,0.000009163082,0.0003263722,0.00001844176,0.0000357234,0.9902607,0.00009970473,0.00008207034,0.004281062],"study_design_scores_gemma":[0.00006078758,0.0005475862,0.1417768,0.00005107548,0.000154587,0.01464363,0.0002766149,0.00378473,0.8271686,0.0003869034,0.01112499,0.00002360908],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956461,0.0007515884,0.002667718,0.0001482614,0.00001448443,0.00001073105,0.000168238,0.00005989788,0.0005329062],"genre_scores_gemma":[0.9968353,0.0002941976,0.001391139,0.00006077148,0.00001152551,0.000004898211,0.0004346662,0.00001239403,0.0009550634],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009944191,"threshold_uncertainty_score":0.003326654,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01952451005614125,"score_gpt":0.2934600482450416,"score_spread":0.2739355381889004,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}