{"id":"W2591761690","doi":"10.1182/blood.v124.21.4778.4778","title":"Combination Therapy with Reovirus and Immunomodulatory Drugs Induces Direct Oncolytic and Immune-Mediated Killing of Multiple Myeloma Cells and Overcomes Stromal-Mediated Microenvironmental Protection","year":2014,"lang":"en","type":"article","venue":"Blood","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Oncolytics Biotech (Canada)","funders":"","keywords":"Stromal cell; Immune system; Oncolytic virus; Context (archaeology); Immunology; Cancer research; Biology; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000144201,0.0003559252,0.0004161341,0.0003245045,0.0001058543,0.0003041159,0.0002242322,0.0002222614,0.001446647],"category_scores_gemma":[0.00008722932,0.00009463508,0.0002566416,0.0001998472,0.0001458937,0.0001471556,0.0001812155,0.000461682,0.0003286156],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002120022,"about_ca_system_score_gemma":0.0001562983,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000513858,"about_ca_topic_score_gemma":0.0009345908,"domain_scores_codex":[0.9998215,0.00003694604,0.00001611272,0.00003219536,0.00003790387,0.00005543259],"domain_scores_gemma":[0.9999238,0.00002264287,0.00001414196,0.00001471744,0.000007701382,0.00001682042],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005634856,0.0001872583,0.0003074735,0.00006917543,0.00001893405,0.00004480051,0.0000203019,0.0002250101,0.9916744,0.00007779488,0.00009723154,0.006714187],"study_design_scores_gemma":[0.00007397078,0.003035942,0.002870341,0.000007131514,0.00003667127,0.0002198158,0.00001462883,0.0006622722,0.9900586,0.00002344288,0.002992857,0.00000429205],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9899277,0.004274599,0.002280908,0.00006473543,0.00006023438,0.00009343235,0.0002778402,0.00009441208,0.002926163],"genre_scores_gemma":[0.9946687,0.001176432,0.002136173,0.00003034039,0.00002761196,0.0000401828,0.0002684752,0.00001179075,0.00164027],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001446647,"threshold_uncertainty_score":0.00483948,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006797090644802705,"score_gpt":0.2108923998706535,"score_spread":0.2040953092258508,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}