{"id":"W2591891548","doi":"10.1182/blood.v128.22.4719.4719","title":"Preclinical Characterization of TTI-281, a Novel, Orally Bioavailable BET Inhibitor: Predictive Biomarker Identification and Combination Treatment Analysis","year":2016,"lang":"en","type":"article","venue":"Blood","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; Trillium Therapeutics (Canada)","funders":"","keywords":"Biomarker; Medicine; Pharmacology; Vorinostat; Oncology; Biology; Gene; Histone deacetylase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005101283,0.0005485545,0.0006910359,0.0006069894,0.0001501887,0.0004144854,0.0003516528,0.0002883397,0.001399547],"category_scores_gemma":[0.0003796011,0.0001818004,0.0003370105,0.0003847574,0.0002250747,0.0002462951,0.0001433987,0.0007467175,0.0003514006],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005415211,"about_ca_system_score_gemma":0.0004473965,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007357555,"about_ca_topic_score_gemma":0.001169,"domain_scores_codex":[0.9998308,0.00003128973,0.00001165698,0.00003118642,0.000065498,0.00002947736],"domain_scores_gemma":[0.9997726,0.00004705552,0.00005404278,0.0000225613,0.00004888331,0.00005489482],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002674651,0.002324308,0.007174557,0.0001981,0.0001354904,0.000142993,0.00004962632,0.006480878,0.9467211,0.0001616295,0.0007585575,0.03317806],"study_design_scores_gemma":[0.000689951,0.0366388,0.02131904,0.00002314244,0.0003999436,0.0005759923,0.0000652397,0.02570919,0.9074203,0.0001503845,0.00697374,0.00003442628],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9883392,0.003159018,0.004367291,0.0001626972,0.00003070164,0.0003980527,0.00173273,0.0001342113,0.001676114],"genre_scores_gemma":[0.9905285,0.001653107,0.003567628,0.00009214188,0.00001599241,0.0002389559,0.002249445,0.0000235093,0.001630708],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001399547,"threshold_uncertainty_score":0.004681945,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01628726111584643,"score_gpt":0.2588543542264236,"score_spread":0.2425670931105772,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}