{"id":"W2591902475","doi":"10.1016/j.stem.2017.02.010","title":"Bringing a Leukemic Stem Cell Gene Signature into Clinics: Are We There Yet?","year":2017,"lang":"en","type":"letter","venue":"Cell stem cell","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute for Research in Immunology and Cancer; Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"","keywords":"Biology; Stem cell; Gene; Gene signature; Signature (topology); Genetics; Cell; Cell biology; Computational biology; Cancer research; Evolutionary biology; Bioinformatics; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["metaepi_narrow","research_integrity"],"category_scores_codex":[0.001021616,0.0016653,0.002491716,0.000690866,0.0006308504,0.0004160945,0.00271743,0.004750091,0.0006194384],"category_scores_gemma":[0.00001993656,0.001491269,0.001096155,0.0003549111,0.0003686377,0.0002224656,0.001166449,0.01299712,0.003419139],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002870508,"about_ca_system_score_gemma":0.002283882,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001812077,"about_ca_topic_score_gemma":0.00001141306,"domain_scores_codex":[0.9914171,0.0004965663,0.001404059,0.00248129,0.00192882,0.002272187],"domain_scores_gemma":[0.9916784,0.0008292316,0.001762558,0.004510859,0.0005418501,0.000677136],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001773271,0.0001323259,0.0003328919,0.01005539,0.0001862064,0.01331837,0.0009219378,0.00002043579,0.01679327,3.883522e-7,0.9525312,0.005530279],"study_design_scores_gemma":[0.004122768,0.0003578844,0.00003944289,0.002056831,0.0006114259,0.0001664603,0.000859137,0.0005402086,0.05983761,0.00002708622,0.9299433,0.001437795],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"other","genre_scores_codex":[0.1912069,0.2154448,0.0005463787,0.2959235,0.00959257,0.01173266,0.0008629162,0.001958448,0.2727318],"genre_scores_gemma":[0.07199438,0.01106918,0.0009637968,0.1184636,0.01426131,0.0002402606,0.001019448,0.001347093,0.7806409],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.5079091,"threshold_uncertainty_score":0.9996094,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03170971767383009,"score_gpt":0.2859833727700769,"score_spread":0.2542736550962468,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}