{"id":"W2591906943","doi":"10.1016/j.canlet.2017.02.027","title":"Resistance to metronomic chemotherapy and ways to overcome it","year":2017,"lang":"en","type":"review","venue":"Cancer Letters","topic":"Angiogenesis and VEGF in Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":false,"ca_institutions":"Health Sciences Centre; University of Toronto; Sunnybrook Health Science Centre","funders":"National Institute on Minority Health and Health Disparities; National Institute of General Medical Sciences; National Cancer Institute","keywords":"Chemotherapy; Context (archaeology); Medicine; Cancer; Resistance (ecology); Drug resistance; Bioinformatics; Cancer research; Oncology; Intensive care medicine; Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001247959,0.0003788448,0.0007810498,0.00008096018,0.0001145892,0.0000739273,0.0004891299,0.0001982707,0.00004983817],"category_scores_gemma":[0.00001818104,0.0003407676,0.0002977101,0.00006554665,0.00006056999,0.000003402601,0.0001562218,0.00009173962,0.00004263647],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001537132,"about_ca_system_score_gemma":0.0001521055,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003506682,"about_ca_topic_score_gemma":0.0001206877,"domain_scores_codex":[0.9985409,0.00002301585,0.0002700009,0.0007268824,0.00009846692,0.0003407424],"domain_scores_gemma":[0.9988145,0.00001052262,0.0001751323,0.0007834898,0.0000265451,0.000189766],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004041216,0.000007128075,0.0000245782,0.001324228,0.0002976607,0.000003211289,0.00003197823,0.000004097236,0.002240592,0.00001600964,0.3460693,0.6499408],"study_design_scores_gemma":[0.000141668,0.00003093854,0.00003880849,0.001489312,0.0001146174,0.000001990857,0.000001557401,6.391512e-8,0.0003475085,0.000001153527,0.9973955,0.0004368365],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003419406,0.9951859,0.0008372748,0.002129142,0.0004275244,0.0005337662,0.0001640355,0.000008077799,0.0003723983],"genre_scores_gemma":[0.00004423629,0.9832909,0.0006144438,0.01210039,0.001201353,0.000416395,0.00004275769,0.00008590253,0.002203592],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.6513262,"threshold_uncertainty_score":0.9999045,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07122877963599807,"score_gpt":0.3679527493588789,"score_spread":0.2967239697228808,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}