{"id":"W2592003520","doi":"10.1182/blood.v112.11.249.249","title":"Preclinical Studies Using Polyethylenimine (PEI) Nanoparticles Complexed with Eukaryotic Translation Initiation Factor 5A (eIF5A) siRNA and eIF5AK50R Plasmid DNA Demonstrates Significant Anti-Myeloma Activity in Vitro and in Vivo","year":2008,"lang":"en","type":"article","venue":"Blood","topic":"Polyamine Metabolism and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"","keywords":"Propidium iodide; Molecular biology; Biology; In vivo; Apoptosis; Initiation factor; In vitro; Annexin; Small interfering RNA; Messenger RNA; Transfection; Translation (biology); Flow cytometry; Cancer research; Programmed cell death; Cell culture; Biochemistry; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001001706,0.0001590299,0.0002519964,0.00006794881,0.0000918798,0.0000143717,0.00005075279,0.00008838905,0.00000110345],"category_scores_gemma":[0.00004866547,0.0001415324,0.00002203141,0.0001346991,0.0002277011,0.00002135757,0.00003218238,0.00008415218,2.320212e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005467646,"about_ca_system_score_gemma":0.00005678318,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002931298,"about_ca_topic_score_gemma":0.0001359718,"domain_scores_codex":[0.9990364,0.00009046798,0.0002503374,0.0003321449,0.0000903094,0.0002003918],"domain_scores_gemma":[0.9996061,0.00008432379,0.00009070257,0.0001271433,0.00003077892,0.00006093298],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001567415,0.0002715396,0.1001617,0.00002169667,0.00003223727,0.000005809233,0.0001655053,0.00001821783,0.8985211,0.000003421547,0.000001058007,0.0006410147],"study_design_scores_gemma":[0.00153095,0.00008659463,0.2989982,0.00001370846,0.00003276121,0.00002609449,0.00006876526,0.0003247215,0.6987684,0.00001501378,0.000007018526,0.0001276859],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978321,0.00155797,0.00008100796,0.0001215397,0.00001333364,0.000286931,0.00008561558,0.00001048953,0.00001101304],"genre_scores_gemma":[0.9979113,0.0006258842,0.00133805,0.0000243083,0.00003897154,0.00002372478,0.0000237136,0.00001154104,0.000002524798],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1997526,"threshold_uncertainty_score":0.5771524,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06592297567674045,"score_gpt":0.2994116253913918,"score_spread":0.2334886497146513,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}