{"id":"W2592003520","doi":"10.1182/blood.v112.11.249.249","title":"Preclinical Studies Using Polyethylenimine (PEI) Nanoparticles Complexed with Eukaryotic Translation Initiation Factor 5A (eIF5A) siRNA and eIF5AK50R Plasmid DNA Demonstrates Significant Anti-Myeloma Activity in Vitro and in Vivo","year":2008,"lang":"en","type":"article","venue":"Blood","topic":"Polyamine Metabolism and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"","keywords":"Propidium iodide; Molecular biology; Biology; In vivo; Apoptosis; Initiation factor; In vitro; Annexin; Small interfering RNA; Messenger RNA; Transfection; Translation (biology); Flow cytometry; Cancer research; Programmed cell death; Cell culture; Biochemistry; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003550578,0.0006584338,0.0004825329,0.0003085562,0.0001686227,0.0002825591,0.0003696553,0.0005690929,0.001846585],"category_scores_gemma":[0.000146594,0.0002223667,0.0003690869,0.0001737508,0.0003069361,0.0003126292,0.0001069883,0.001185934,0.0004626076],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003767841,"about_ca_system_score_gemma":0.0003627361,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000700813,"about_ca_topic_score_gemma":0.001064345,"domain_scores_codex":[0.9998863,0.00001843981,0.000006626062,0.00002414674,0.00003838546,0.00002610125],"domain_scores_gemma":[0.9998753,0.00002252019,0.00003529666,0.0000111022,0.00002096992,0.00003475245],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001342003,0.00213398,0.0001918311,0.0001743206,0.00005519175,0.0000788729,0.00004440199,0.0006291085,0.984213,0.0001642249,0.0004013013,0.01057176],"study_design_scores_gemma":[0.0004027927,0.02517324,0.001744334,0.00001695197,0.00009754358,0.0001982717,0.00002527892,0.001796448,0.9659521,0.00006232177,0.004520074,0.00001073408],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9775929,0.004204739,0.01088158,0.000385707,0.0003150617,0.0005390058,0.0004609509,0.0005418727,0.005078029],"genre_scores_gemma":[0.984054,0.002524051,0.004327996,0.0001166624,0.00004428994,0.0003693788,0.0005744297,0.00004333073,0.007945719],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001846585,"threshold_uncertainty_score":0.006177425,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06592297567674045,"score_gpt":0.2994116253913918,"score_spread":0.2334886497146513,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}