{"id":"W2592016869","doi":"10.1194/jlr.r075556","title":"Therapeutic potential of nuclear receptor agonists in Alzheimer's disease","year":2017,"lang":"en","type":"review","venue":"Journal of Lipid Research","topic":"Nuclear Receptors and Signaling","field":"Neuroscience","cited_by":74,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; W. Garfield Weston Foundation; Weston Brain Institute","keywords":"Neuroscience; Disease; Context (archaeology); Nuclear receptor; Alzheimer's disease; Medicine; Therapeutic approach; Inflammation; Transcription factor; Bioinformatics; Biology; Gene; Internal medicine; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003482505,0.0002827171,0.001567879,0.001055844,0.0003091126,0.000271519,0.002038188,0.0002452311,0.0008771934],"category_scores_gemma":[0.001344276,0.0002029756,0.0008822298,0.0004553546,0.0005197816,0.0002682882,0.0003481675,0.00226631,0.0001963871],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001395408,"about_ca_system_score_gemma":0.001006611,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001020989,"about_ca_topic_score_gemma":5.207165e-7,"domain_scores_codex":[0.9939972,0.002009287,0.001273116,0.0003807242,0.00175687,0.0005828537],"domain_scores_gemma":[0.9968122,0.0005621237,0.00132953,0.0006065291,0.0002988986,0.0003907831],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002330756,0.0003336766,0.000005442646,0.002074588,0.00009784175,0.0002997698,0.0000912744,0.000003974073,0.001893993,0.0002927009,0.002558332,0.9921153],"study_design_scores_gemma":[0.000284383,0.0002444698,0.000009725917,0.008050603,0.0001391842,0.0000713595,0.00002088784,0.00001960068,0.00008584461,0.0001085205,0.9907844,0.0001810155],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0004287163,0.9969325,0.000001270026,0.000228688,0.001253305,0.0004492564,0.00002574418,0.000006382396,0.0006741219],"genre_scores_gemma":[0.005750986,0.9926353,0.00004589657,0.00002047041,0.001269341,0.000003867319,0.000001144617,0.00009753985,0.0001754821],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9919343,"threshold_uncertainty_score":0.9846115,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3765323520367176,"score_gpt":0.480934566690761,"score_spread":0.1044022146540433,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}