{"id":"W2592097368","doi":"10.1021/acs.chemrestox.6b00430","title":"Lipidomic Evaluation of Aryl Hydrocarbon Receptor-Mediated Hepatic Steatosis in Male and Female Mice Elicited by 2,3,7,8-Tetrachlorodibenzo-<i>p</i>-dioxin","year":2017,"lang":"en","type":"article","venue":"Chemical Research in Toxicology","topic":"Adipose Tissue and Metabolism","field":"Medicine","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; National Institute of Environmental Health Sciences; Canadian Institutes of Health Research; Michigan State University","keywords":"Aryl hydrocarbon receptor; Steatosis; Tetrachlorodibenzo-p-dioxin; Aryl; Internal medicine; Hydrocarbon; Receptor; Endocrinology; Chemistry; Biology; Medicine; Biochemistry; Toxicity; Organic chemistry; Transcription factor; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001336079,0.0003414469,0.0003344976,0.0007282704,0.0001953643,0.000256398,0.0001333128,0.0003418336,0.001218546],"category_scores_gemma":[0.00009979461,0.0002485325,0.0003079244,0.0003977432,0.0002397582,0.0001866056,0.0002264039,0.0005552105,0.0003380332],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001995862,"about_ca_system_score_gemma":0.0001265239,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007966844,"about_ca_topic_score_gemma":0.00133157,"domain_scores_codex":[0.9998567,0.00001214899,0.000007427132,0.0000524487,0.00003690501,0.00003438587],"domain_scores_gemma":[0.9998463,0.00001255832,0.00004811197,0.00001029469,0.00003482171,0.00004782751],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003857583,0.00001368017,0.0011945,0.00002661202,0.00001281709,0.00003752219,0.00002103231,0.00002979515,0.9974432,0.00002692468,0.00004063478,0.0007674624],"study_design_scores_gemma":[0.00004059288,0.0008828552,0.1341669,0.00002366897,0.0001550764,0.0004894389,0.0002077205,0.00134144,0.8591729,0.0001551077,0.003329798,0.00003460157],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9883444,0.001327168,0.003550943,0.0001007395,0.00003704284,0.00003632921,0.005264699,0.000144113,0.001194609],"genre_scores_gemma":[0.977836,0.002282573,0.004443331,0.0003763734,0.00002249286,0.0001853445,0.006476267,0.0001272575,0.008250509],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001218546,"threshold_uncertainty_score":0.004076481,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09156039124713831,"score_gpt":0.4041947834577072,"score_spread":0.3126343922105688,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}