{"id":"W2592114706","doi":"10.1182/blood.v110.11.4545.4545","title":"BCR-ABL Induces Autocrine IGF-1 Signaling.","year":2007,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"","keywords":"Autocrine signalling; Cancer research; Imatinib mesylate; breakpoint cluster region; Chronic myelogenous leukemia; Biology; Signal transduction; Tyrosine kinase; Imatinib; Cell biology; Leukemia; Immunology; Cell culture; Receptor; Myeloid leukemia; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008225381,0.0003017368,0.0001278607,0.0001600421,0.0001128977,0.0001673721,0.0001076196,0.0001806431,0.003017902],"category_scores_gemma":[0.00006289015,0.0001056713,0.0001741744,0.00008801633,0.0001379545,0.0001090607,0.0001706663,0.0006497732,0.0005633217],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003688559,"about_ca_system_score_gemma":0.0001812642,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007341289,"about_ca_topic_score_gemma":0.001528712,"domain_scores_codex":[0.999897,0.00001234382,0.000006656833,0.00001972291,0.00004206606,0.00002215654],"domain_scores_gemma":[0.9999557,0.000009161561,0.00001135876,0.000005545687,0.000005103735,0.00001323469],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008081156,0.00002911836,0.0001842747,0.00004815452,0.000003567246,0.00003003981,0.000006274448,0.00004896857,0.9974036,0.0000922823,0.0001680064,0.001904807],"study_design_scores_gemma":[0.00005786855,0.0004247176,0.007438074,0.00001225737,0.00001351713,0.0002725301,0.00002206617,0.001027281,0.981729,0.00007311316,0.008925361,0.000004222804],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9816291,0.005710865,0.003772506,0.0004379225,0.0001645897,0.0001008121,0.002712234,0.0001993474,0.005272583],"genre_scores_gemma":[0.9907621,0.001029299,0.001797113,0.0001439253,0.00001356731,0.0000627443,0.001723597,0.0000105505,0.004457153],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003017902,"threshold_uncertainty_score":0.01009589,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01927580072323565,"score_gpt":0.2817426360693515,"score_spread":0.2624668353461159,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}