{"id":"W2592137822","doi":"10.1182/blood.v128.22.1895.1895","title":"Treatment-Free Remission (TFR) in Patients with Chronic Phase Chronic Myeloid Leukemia (CML-CP) and in Stable Deep Molecular Response (DMR) to Dasatinib - the Dasfree Study","year":2016,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"","keywords":"Dasatinib; Discontinuation; Medicine; Internal medicine; Clinical endpoint; Oncology; Imatinib; Drug holiday; Surrogate endpoint; Myeloid leukemia; Clinical trial; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002962549,0.000728956,0.001409679,0.000339345,0.0003630304,0.000970171,0.0005382795,0.001005619,0.001766208],"category_scores_gemma":[0.001621228,0.0003275021,0.00155416,0.0005413126,0.0004989823,0.001029394,0.0007501395,0.001946997,0.0005120995],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007076841,"about_ca_system_score_gemma":0.0008847172,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007553703,"about_ca_topic_score_gemma":0.002390188,"domain_scores_codex":[0.9988542,0.0005352181,0.0000985488,0.0002182846,0.0001356514,0.0001581599],"domain_scores_gemma":[0.9984362,0.0002023431,0.0004786623,0.0001333926,0.00009593124,0.0006534603],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6697611,0.01363773,0.1825764,0.001809805,0.004708997,0.0003651857,0.0005035443,0.001961396,0.01055563,0.0004356782,0.008188416,0.105496],"study_design_scores_gemma":[0.301641,0.2635628,0.4112647,0.0001811355,0.003020992,0.0008030242,0.0002661956,0.001269409,0.002199044,0.0006863785,0.01499926,0.0001061172],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9871123,0.004126656,0.0003032185,0.0004928811,0.0001065451,0.001179052,0.004939987,0.00002874787,0.00171076],"genre_scores_gemma":[0.988976,0.001081551,0.0005587876,0.0008466208,0.0001604914,0.0009554958,0.006687662,0.00000870075,0.0007248209],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002962549,"threshold_uncertainty_score":0.01566762,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009186561493443199,"score_gpt":0.2607091870981696,"score_spread":0.2515226256047264,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}