{"id":"W2592145184","doi":"10.1021/jacs.6b11533","title":"<sup>18</sup>F-Fluorination of Unactivated C–H Bonds in Branched Aliphatic Amino Acids: Direct Synthesis of Oncological Positron Emission Tomography Imaging Agents","year":2017,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Amino Acid Enzymes and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":136,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency; TRIUMF; Simon Fraser University","funders":"Canadian Cancer Society Research Institute; Michael Smith Health Research BC; Natural Sciences and Engineering Research Council of Canada; F. Hoffmann-La Roche","keywords":"Chemistry; Positron emission tomography; Biodistribution; Amino acid; Radiochemistry; Prostate cancer; Leucine; Cancer research; Cancer; Combinatorial chemistry; Nuclear medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003898644,0.0001547952,0.0004885339,0.00002945052,0.00007329875,0.00001469823,0.000575189,0.00009663113,0.00000897898],"category_scores_gemma":[0.0005266808,0.0001048228,0.0005331662,0.0001494783,0.0004694712,0.00001818966,0.0002068171,0.0002020265,1.003686e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005425012,"about_ca_system_score_gemma":0.0000606548,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005255421,"about_ca_topic_score_gemma":2.872311e-7,"domain_scores_codex":[0.9987431,0.0001055752,0.0004826059,0.0001777357,0.000284649,0.0002063119],"domain_scores_gemma":[0.9979993,0.00006479303,0.00135441,0.0003591906,0.0001428228,0.00007951717],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001543796,0.0001848575,0.04710821,0.0000232641,0.0001139676,0.000001078149,0.0001040644,0.00004504929,0.9453287,0.00000212011,0.0009229424,0.006011368],"study_design_scores_gemma":[0.0005240779,0.00009363975,0.1146038,0.00008835767,0.00008631442,0.00001053542,0.0002071668,0.0003168378,0.8833832,0.0000339064,0.0005484932,0.0001036724],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986952,0.0002965965,0.00007481525,0.0003525175,0.00004501645,0.00008350197,0.000009368146,0.000002557033,0.0004404543],"genre_scores_gemma":[0.9982553,0.0003372605,0.001096554,0.000128049,0.000126139,0.000003479256,0.000002895197,0.00001367877,0.00003661557],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06749558,"threshold_uncertainty_score":0.427455,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009754739094187155,"score_gpt":0.2723895551139965,"score_spread":0.2626348160198093,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}