{"id":"W2592147130","doi":"10.1093/biolreprod/85.s1.562","title":"Ligand-Induced Activation of Translocator Protein (TSPO) Induces Cholesterol Transport and Steroidogenesis in Aged Leydig Cells.","year":2011,"lang":"en","type":"article","venue":"Biology of Reproduction","topic":"Hormonal and reproductive studies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"","keywords":"Translocator protein; Testosterone (patch); Endocrinology; Biology; Leydig cell; Internal medicine; Steroidogenic acute regulatory protein; Cholesterol; Cholesterol side-chain cleavage enzyme; Inflammation; Hormone; Cytochrome P450; Biochemistry; Gene expression; Metabolism; Immunology; Medicine; Luteinizing hormone","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001189767,0.0002255075,0.0002240055,0.000176433,0.0001287326,0.0001693331,0.0001022155,0.0001417253,0.0009704064],"category_scores_gemma":[0.00009142702,0.0001081852,0.0002852355,0.0001360088,0.0001931528,0.0001650119,0.0001887073,0.000264898,0.0002613144],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002522045,"about_ca_system_score_gemma":0.0001682981,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007735416,"about_ca_topic_score_gemma":0.001455186,"domain_scores_codex":[0.9998982,0.00001371187,0.000009561501,0.00002259533,0.00002229628,0.00003365841],"domain_scores_gemma":[0.9998847,0.00001182495,0.00003992338,0.000009167361,0.00001158345,0.00004276443],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001566868,0.00001893934,0.0004166786,0.00003383906,0.000005693301,0.00009933598,0.00002265145,0.00001499522,0.998566,0.0000284257,0.00002659381,0.0006102332],"study_design_scores_gemma":[0.00003614265,0.001753395,0.04447999,0.000008170308,0.00004718087,0.001339982,0.0001392797,0.0004458982,0.9467196,0.00005716027,0.004962057,0.00001112147],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947298,0.003631846,0.0007122927,0.00005060248,0.00003520371,0.00001466501,0.000269157,0.00003467869,0.0005217014],"genre_scores_gemma":[0.9947572,0.001816338,0.000691831,0.00004432921,0.00002302602,0.00002166247,0.0005433295,0.000007641594,0.002094672],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009704064,"threshold_uncertainty_score":0.003246307,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05247987124281298,"score_gpt":0.2604741672180472,"score_spread":0.2079942959752343,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}