{"id":"W2592196376","doi":"10.1182/blood.v118.21.422.422","title":"Pre-Screening for Low Methyl Guanine Methyltransferase (MGMT) Expression Results in High Response Rates to Temozolomide (TMZ) Therapy in AML and MDS Patients.","year":2011,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"London Health Sciences Centre; McMaster University Medical Centre; Merck Canada Inc. (Canada); Hôpital Maisonneuve-Rosemont; Princess Margaret Cancer Centre","funders":"","keywords":"Temozolomide; Methyltransferase; Medicine; O-6-methylguanine-DNA methyltransferase; Oncology; Internal medicine; Induction chemotherapy; Myeloid leukemia; Chemotherapy; Decitabine; DNA methylation; Methylation; Biology; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006765824,0.0002083957,0.0004238737,0.0003333392,0.0001487806,0.0003393143,0.0001833926,0.0004009601,0.001656888],"category_scores_gemma":[0.001331223,0.0001815423,0.0002236841,0.0002684286,0.0001819742,0.0002259687,0.0001809549,0.0003641937,0.0004578249],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001875392,"about_ca_system_score_gemma":0.0001399722,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002437805,"about_ca_topic_score_gemma":0.0002799976,"domain_scores_codex":[0.9996866,0.0001078881,0.00003385288,0.0000775139,0.0000503502,0.0000437931],"domain_scores_gemma":[0.9991769,0.0002677125,0.0002660018,0.00004915707,0.00004933535,0.0001908448],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01366166,0.0009332657,0.8988822,0.00005028786,0.00008816819,0.0004021621,0.00012306,0.0002216345,0.06292564,0.00003910526,0.0003986145,0.02227421],"study_design_scores_gemma":[0.0004145429,0.007663271,0.9802522,0.000006382439,0.00008940478,0.001544071,0.00006359312,0.0008746837,0.008399666,0.00002915704,0.0006537369,0.000009389419],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.999521,0.0001540508,0.00007453666,0.00001899241,0.000002462161,0.00001307795,0.00005858037,0.000006142921,0.0001511324],"genre_scores_gemma":[0.99938,0.00003826437,0.000178595,0.00002587204,0.000006531676,0.00001397117,0.0001910376,0.00000233475,0.000163381],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001656888,"threshold_uncertainty_score":0.005542874,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03785284742677013,"score_gpt":0.313503723307652,"score_spread":0.2756508758808818,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}