{"id":"W2592248586","doi":"10.1093/nar/gkx153","title":"Antibiotics trigger initiation of SCCmec transfer by inducing SOS responses","year":2017,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Repressor lexA; SCCmec; Biology; SOS response; Microbiology; Antibiotics; Antibiotic resistance; Horizontal gene transfer; Mobile genetic elements; Regulon; Genetics; Repressor; Gene; Regulation of gene expression; Methicillin-resistant Staphylococcus aureus; Gene expression; Plasmid; Staphylococcus aureus; DNA repair; Bacteria; Genome","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001120649,0.0004118647,0.0003603086,0.0002431039,0.0001419593,0.0003146098,0.00009938265,0.0003957498,0.00336324],"category_scores_gemma":[0.0002325254,0.0001440798,0.0003509744,0.0001005584,0.0001871155,0.0001966381,0.000387264,0.0007628305,0.0008863465],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002605223,"about_ca_system_score_gemma":0.0002158613,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004985635,"about_ca_topic_score_gemma":0.0006360642,"domain_scores_codex":[0.9997192,0.00005424462,0.00001642339,0.00004780428,0.00007714422,0.00008520995],"domain_scores_gemma":[0.9997504,0.00006294879,0.00005987217,0.00002975692,0.00005121567,0.00004578286],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006621815,0.00002019349,0.0001434556,0.00004529513,0.000002026269,0.00003524959,0.00001222166,0.00001576852,0.9987275,0.00003796809,0.00003904286,0.0008549956],"study_design_scores_gemma":[0.000007506245,0.0002019411,0.006201414,0.00001560835,0.000004207133,0.00007806566,0.00003944925,0.0003193752,0.9908884,0.00004847697,0.002191146,0.000004437385],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9821786,0.005007534,0.006151209,0.0003727067,0.000138581,0.0001404916,0.0007921619,0.0002729312,0.004945641],"genre_scores_gemma":[0.9914277,0.001269448,0.002492847,0.0001505178,0.00002157087,0.00006816106,0.0004802039,0.00003618212,0.004053487],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00336324,"threshold_uncertainty_score":0.01125121,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05925088055994879,"score_gpt":0.3708860312409464,"score_spread":0.3116351506809976,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}