{"id":"W2592263424","doi":"10.1080/15548627.2017.1291470","title":"The peroxisomal AAA ATPase complex prevents pexophagy and development of peroxisome biogenesis disorders","year":2017,"lang":"en","type":"article","venue":"Autophagy","topic":"Peroxisome Proliferator-Activated Receptors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":116,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; McGill University; Hospital for Sick Children; University of Toronto","funders":"","keywords":"Peroxisome; Biology; AAA proteins; Cell biology; Biogenesis; Mutation; Zellweger syndrome; ATPase; Biochemistry; Gene; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001582564,0.0003355534,0.0002480694,0.0003735023,0.0001713069,0.0002515626,0.0002436739,0.0004504184,0.002138606],"category_scores_gemma":[0.0002809514,0.0001271363,0.0001622315,0.0001081467,0.00024258,0.0001533157,0.0003078543,0.0005691344,0.0005619965],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001687321,"about_ca_system_score_gemma":0.0002308507,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002778707,"about_ca_topic_score_gemma":0.0002983314,"domain_scores_codex":[0.9998935,0.00002317409,0.00001698327,0.00002266915,0.00002491838,0.00001873828],"domain_scores_gemma":[0.9998337,0.00002448291,0.00005100371,0.00001725153,0.00001966492,0.00005382546],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004658552,0.0001153076,0.001613054,0.00008228586,0.00003026423,0.0005543134,0.00001920151,0.0001021497,0.9872819,0.001014056,0.0003550345,0.00836671],"study_design_scores_gemma":[0.000136978,0.0005511653,0.02654783,0.00005143193,0.00007240211,0.005607333,0.00005364477,0.001049847,0.9431794,0.0008184287,0.0219182,0.00001350215],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9781095,0.006159476,0.008066575,0.0006932699,0.0001591044,0.0000533969,0.0004438411,0.0003039895,0.006010702],"genre_scores_gemma":[0.9929184,0.001366342,0.002145081,0.0000938257,0.00002288218,0.00002814108,0.0003577846,0.00003699456,0.003030619],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002138606,"threshold_uncertainty_score":0.007154405,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01838929064781528,"score_gpt":0.2723759900245392,"score_spread":0.2539866993767239,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}