{"id":"W2592269524","doi":"10.1182/blood.v112.11.4217.4217","title":"Direct Interaction of Ahi-1 with BCR-ABL Modulates BCR-ABL Transforming Activity and Imatinib Response in a BCR-ABL Inducible Cell Line Model","year":2008,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"","keywords":"Cancer research; Progenitor cell; Biology; ABL; Imatinib mesylate; Chronic myelogenous leukemia; K562 cells; breakpoint cluster region; Stem cell; Tyrosine kinase; Haematopoiesis; Myeloid leukemia; Imatinib; Leukemia; Cell biology; Immunology; Signal transduction; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000162964,0.000317402,0.000288442,0.0001908983,0.000163971,0.0003136326,0.000269502,0.0003160356,0.001476008],"category_scores_gemma":[0.0000670529,0.000112653,0.000243509,0.00020338,0.0001575654,0.0001546153,0.0002102679,0.001012534,0.0005813265],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002703639,"about_ca_system_score_gemma":0.0001637806,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006272266,"about_ca_topic_score_gemma":0.000894083,"domain_scores_codex":[0.9997318,0.00003400206,0.00002619781,0.00004109116,0.00009983045,0.00006696459],"domain_scores_gemma":[0.9999193,0.00001162127,0.0000197397,0.00001137365,0.00001025399,0.00002769656],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006984658,0.00006571668,0.00007191031,0.00001483116,0.000002869185,0.00002312527,0.00001079717,0.00003642069,0.9992886,0.00007198605,0.00005588654,0.0002881714],"study_design_scores_gemma":[0.00002612827,0.0003584927,0.001944288,0.000002879878,0.0000121815,0.00007248513,0.00003087766,0.001199434,0.9939619,0.00003015168,0.002356858,0.000004267543],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946167,0.0007570639,0.00188365,0.0001301403,0.00006715871,0.00005441085,0.0008350014,0.0001087527,0.001547236],"genre_scores_gemma":[0.9943835,0.0003847822,0.001417353,0.00004524174,0.000009753729,0.00007491466,0.0009286544,0.00001827764,0.002737588],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001476008,"threshold_uncertainty_score":0.004937768,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02433118919529282,"score_gpt":0.2647605900314692,"score_spread":0.2404294008361764,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}