{"id":"W2592299281","doi":"10.1002/iub.1611","title":"Dynamics of the metal binding domains and regulation of the human copper transporters ATP7B and ATP7A","year":2017,"lang":"en","type":"review","venue":"IUBMB Life","topic":"Trace Elements in Health","field":"Nursing","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Canadian Institutes of Health Research; Saskatchewan Health Research Foundation","keywords":"ATP7A; ATPase; Menkes disease; Transporter; Copper; Chemistry; Cytosol; Biochemistry; Transport protein; Enzyme; Intracellular; P-type ATPase; Protein structure; Cell biology; Biology; Copper metabolism; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006047364,0.0002565571,0.000955924,0.00008559919,0.0004052772,0.00002725326,0.0004147781,0.0002245702,0.000007864139],"category_scores_gemma":[0.00006808477,0.0001533408,0.0002575949,0.0001156446,0.0004263817,0.00009295314,0.00007336361,0.0003319876,4.424705e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001261809,"about_ca_system_score_gemma":0.0001098385,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009506077,"about_ca_topic_score_gemma":0.0003479252,"domain_scores_codex":[0.99814,0.0002617669,0.0007489709,0.0002838783,0.0003450606,0.0002202944],"domain_scores_gemma":[0.9977499,0.0001406024,0.001242139,0.0007680762,0.00003437867,0.00006492478],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004059863,0.0001395502,0.0244972,0.05246976,0.000695669,0.000001396395,0.001668361,0.000005369967,0.00008799791,0.006334628,0.0005540348,0.9135054],"study_design_scores_gemma":[0.002575862,0.0003104009,0.2261099,0.05918531,0.008690058,0.00007867075,0.0004226772,0.00009354149,0.00009971701,0.0009661384,0.7001823,0.001285461],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.099062,0.8955398,0.000007598473,0.000713826,0.001592771,0.002104778,0.0005125157,0.00002602666,0.0004406814],"genre_scores_gemma":[0.30216,0.6967124,0.0002148487,0.00006962108,0.0002384963,0.00003425801,0.00008620403,0.0001278209,0.0003563312],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.91222,"threshold_uncertainty_score":0.6253057,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08467370664845424,"score_gpt":0.3836117505850811,"score_spread":0.2989380439366269,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}