{"id":"W2592299719","doi":"10.1200/jco.2013.31.15_suppl.4031","title":"A multicenter, randomized, blinded, phase III study of pasireotide LAR versus octreotide LAR in patients with metastatic neuroendocrine tumors (NET) with disease-related symptoms inadequately controlled by somatostatin analogs.","year":2013,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Neuroendocrine Tumor Research Advances","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Foothills Medical Centre","funders":"","keywords":"Medicine; Pasireotide; Lanreotide; Octreotide; Gastroenterology; Internal medicine; Neuroendocrine tumors; Somatostatin; Interim analysis; Phases of clinical research; Abdominal pain; Mallinckrodt; Clinical endpoint; Tolerability; Adverse effect; Randomized controlled trial; Clinical trial; Acromegaly; Hormone","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001862277,0.0004829993,0.00588108,0.000602367,0.0000548745,0.0000280705,0.0004065034,0.00002426578,0.0001627931],"category_scores_gemma":[0.01258052,0.0002775594,0.0005130603,0.000601534,0.0007629201,0.000480137,0.0001080447,0.001701025,0.00001228636],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001467428,"about_ca_system_score_gemma":0.001088129,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002749737,"about_ca_topic_score_gemma":0.000212483,"domain_scores_codex":[0.9877971,0.003815146,0.005564505,0.0005276403,0.001526262,0.0007693316],"domain_scores_gemma":[0.9835617,0.009189414,0.004427335,0.0004507675,0.001211737,0.001159044],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7654892,0.03193809,0.17755,0.00007438809,0.002292049,0.01924203,0.00007928494,0.0002105764,0.00001654314,0.00001177959,0.0003319228,0.002764153],"study_design_scores_gemma":[0.8648543,0.08589001,0.04474682,0.0002417624,0.001929817,0.0002169084,0.0005742077,0.001156668,0.00003065702,0.00005570274,0.0001003332,0.0002028613],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914129,0.0002774319,0.0000275066,0.001598144,0.0002554219,0.006307987,0.00002228095,0.00002223059,0.00007610242],"genre_scores_gemma":[0.9985369,0.0001677281,0.0005386751,0.0003454052,0.00005375259,0.0001766188,0.00002303294,0.00006622454,0.00009162886],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1328032,"threshold_uncertainty_score":0.9999676,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0411544532521575,"score_gpt":0.4069491457250471,"score_spread":0.3657946924728896,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}