{"id":"W2592299719","doi":"10.1200/jco.2013.31.15_suppl.4031","title":"A multicenter, randomized, blinded, phase III study of pasireotide LAR versus octreotide LAR in patients with metastatic neuroendocrine tumors (NET) with disease-related symptoms inadequately controlled by somatostatin analogs.","year":2013,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Neuroendocrine Tumor Research Advances","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Foothills Medical Centre","funders":"","keywords":"Medicine; Pasireotide; Lanreotide; Octreotide; Gastroenterology; Internal medicine; Neuroendocrine tumors; Somatostatin; Interim analysis; Phases of clinical research; Abdominal pain; Mallinckrodt; Clinical endpoint; Tolerability; Adverse effect; Randomized controlled trial; Clinical trial; Acromegaly; Hormone","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003696067,0.001547379,0.002692307,0.0003535908,0.0004940612,0.001130756,0.0009313888,0.001615016,0.004586376],"category_scores_gemma":[0.002709393,0.0007857063,0.001520093,0.0004566285,0.001347385,0.001133303,0.000447862,0.002944184,0.001017294],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007521244,"about_ca_system_score_gemma":0.001990822,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006803575,"about_ca_topic_score_gemma":0.001664752,"domain_scores_codex":[0.9987531,0.0007823986,0.00006263916,0.0001766536,0.00007560481,0.00014962],"domain_scores_gemma":[0.9983206,0.0004521965,0.0003777544,0.0001323713,0.0001076713,0.0006093123],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9748285,0.01106389,0.0006459369,0.0002334365,0.0005022604,0.00003082019,0.00006315586,0.0003367296,0.003434064,0.00007268245,0.0005478227,0.008240731],"study_design_scores_gemma":[0.8874556,0.1099256,0.001240813,0.00001333402,0.0002085692,0.00002767198,0.00001734069,0.0004152009,0.0002605736,0.00009976759,0.0003264406,0.000009212824],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9838007,0.002170556,0.001274945,0.0006216743,0.000526655,0.008442817,0.001079167,0.0001199809,0.001963449],"genre_scores_gemma":[0.9833356,0.001225822,0.002574487,0.001348786,0.0003697547,0.008144588,0.0009347037,0.00003190456,0.002034356],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004586376,"threshold_uncertainty_score":0.01954693,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0411544532521575,"score_gpt":0.4069491457250471,"score_spread":0.3657946924728896,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}