{"id":"W2592367016","doi":"10.1182/blood.v124.21.2305.2305","title":"CPX-351 Markedly Reduces Renal and Hepatic Clearance Rates for Cytarabine (Cyt) and Daunorubicin (Daun) in Rats with an Associated Decrease in Excretory and Metabolic Burden Despite Providing Dramatic Increases in Systemic Drug Exposure Compared to Conventional Cyt+Daun","year":2014,"lang":"en","type":"article","venue":"Blood","topic":"Acute Lymphoblastic Leukemia research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Celator Pharmaceuticals (Canada)","funders":"","keywords":"Excretion; Pharmacology; Pharmacodynamics; Pharmacokinetics; Saline; Drug; Medicine; Internal medicine; Chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003791756,0.0007899255,0.000543566,0.0007716877,0.0001953682,0.0003908169,0.0004319285,0.0004378874,0.002065463],"category_scores_gemma":[0.0002753833,0.0003806663,0.0003443671,0.0002683142,0.0007021109,0.0005058164,0.0001943515,0.001091068,0.0004617705],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005580981,"about_ca_system_score_gemma":0.0007219359,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001582459,"about_ca_topic_score_gemma":0.001949581,"domain_scores_codex":[0.9997086,0.00004172483,0.00002367246,0.00008201072,0.0000735288,0.00007040082],"domain_scores_gemma":[0.9994466,0.00006459541,0.0002169547,0.00007627841,0.00004178512,0.0001538063],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002763713,0.000284092,0.0001577866,0.00004587427,0.00001446419,0.00002792583,0.00002198904,0.0001568402,0.9939793,0.00007149688,0.00006267669,0.002413857],"study_design_scores_gemma":[0.00007412046,0.004142516,0.001485167,0.000004057012,0.00002298766,0.0000869494,0.0000210885,0.0005325956,0.9931118,0.00001996836,0.0004915774,0.000007174926],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960818,0.0005662148,0.002016265,0.00009507668,0.00003474186,0.00005013157,0.0003844185,0.0002605746,0.0005107557],"genre_scores_gemma":[0.9927599,0.0005626196,0.002620752,0.00004733548,0.00001788608,0.00006419588,0.0005142215,0.00005716036,0.003355892],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002065463,"threshold_uncertainty_score":0.006909609,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01070443073305848,"score_gpt":0.2679464237572189,"score_spread":0.2572419930241604,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}