{"id":"W2592370523","doi":"10.1186/s12867-017-0084-1","title":"Properties of STAT1 and IRF1 enhancers and the influence of SNPs","year":2017,"lang":"en","type":"article","venue":"BMC Molecular Biology","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Lunenfeld-Tanenbaum Research Institute; Dalhousie University","funders":"Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Krembil Foundation","keywords":"In silico; Biology; IRF1; Enhancer; Single-nucleotide polymorphism; SNP; Genetics; STAT1; Gene; Computational biology; Transcription factor; Genotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["sts"],"consensus_categories":[],"category_scores_codex":[0.0002425519,0.00008681909,0.0002463353,0.00003495139,0.0001082513,0.000006264926,0.0002115431,0.0001145306,0.0000124367],"category_scores_gemma":[0.0004430953,0.00005065252,0.00003919243,0.00001175969,0.002788457,0.00002737225,0.0001927215,0.00008369108,0.000003739727],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003887678,"about_ca_system_score_gemma":0.00005324691,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002843203,"about_ca_topic_score_gemma":0.00002100647,"domain_scores_codex":[0.9992372,0.0002913399,0.0001841328,0.0001350919,0.00001015212,0.0001420262],"domain_scores_gemma":[0.9993595,0.00007530831,0.0001798625,0.0003245978,0.00005370293,0.000006995734],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001183853,0.00001064397,0.002341598,0.00003369788,0.0000799039,3.460301e-7,0.0003840309,0.00000119477,0.9882079,0.006627337,0.000006632087,0.001122827],"study_design_scores_gemma":[0.001427467,0.0002050298,0.02817325,0.00003954181,0.00002517277,0.00002654612,0.0001371487,0.000001551002,0.9687858,0.0003107847,0.0008013645,0.00006629807],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9870983,0.0121601,0.0001494388,0.0001116072,0.00007640769,0.0001693987,0.000007145372,0.000004508535,0.0002230546],"genre_scores_gemma":[0.9992329,0.0003595371,0.00004760976,0.00006332192,0.00000230368,0.00001134769,0.000001775636,0.000004548668,0.0002766387],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02583165,"threshold_uncertainty_score":0.9999254,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01183338632464483,"score_gpt":0.2595952327562844,"score_spread":0.2477618464316395,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}