{"id":"W2592376683","doi":"10.2147/hp.s130526","title":"Induction of erythropoiesis by hypoxia-inducible factor prolyl hydroxylase inhibitors without promotion of tumor initiation, progression, or metastasis in a VEGF-sensitive model of spontaneous breast cancer","year":2017,"lang":"en","type":"article","venue":"Hypoxia","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"McGill University; FibroGen","keywords":"Vascular endothelial growth factor; Metastasis; Medicine; Hypoxia (environmental); Hypoxia-inducible factors; Cancer research; Erythropoiesis; Breast cancer; Angiogenesis; Internal medicine; Cancer; Endocrinology; VEGF receptors; Biology; Chemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003254238,0.0004370056,0.0002991434,0.000374097,0.0001647995,0.0002031027,0.0002596452,0.0002710422,0.0009590402],"category_scores_gemma":[0.0001053093,0.0001851135,0.0002764791,0.0001771318,0.0003046528,0.0002266543,0.0001715725,0.0007876134,0.0001913497],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003728363,"about_ca_system_score_gemma":0.0002613154,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006682016,"about_ca_topic_score_gemma":0.001072764,"domain_scores_codex":[0.9998005,0.00004646174,0.00002423064,0.00003570072,0.00004877096,0.00004443841],"domain_scores_gemma":[0.9997539,0.00003665723,0.00007813031,0.0000306457,0.00001546975,0.00008512136],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004608238,0.000191773,0.0001490841,0.00002244178,0.00000496856,0.0000281544,0.0000128992,0.00005280284,0.9982287,0.00008609504,0.00003475411,0.0007274827],"study_design_scores_gemma":[0.00004104503,0.001412108,0.001108834,0.000002590225,0.000009024009,0.00009231486,0.000009682632,0.0003772439,0.9963691,0.00001461862,0.0005613736,0.000002012473],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967467,0.0005074776,0.001528189,0.00006571569,0.00002263776,0.00005786556,0.0003696112,0.00006437,0.0006374166],"genre_scores_gemma":[0.9911417,0.0005986345,0.003728813,0.00004188672,0.00001550296,0.0001324307,0.0007213965,0.00003578152,0.003583858],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009590402,"threshold_uncertainty_score":0.00320828,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02560561581191545,"score_gpt":0.2932401286755684,"score_spread":0.2676345128636529,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}