{"id":"W2592518050","doi":"10.1038/ng.3916","title":"Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease","year":2017,"lang":"en","type":"article","venue":"Nature Genetics","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":1104,"is_retracted":false,"has_abstract":false,"ca_institutions":"Occupational Cancer Research Centre; University of Toronto","funders":"National Center for Research Resources; National Institute of Neurological Disorders and Stroke; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute on Deafness and Other Communication Disorders; National Eye Institute; National Human Genome Research Institute; National Institute of Mental Health; National Heart, Lung, and Blood Institute; National Institute on Aging; National Cancer Institute; European Regional Development Fund; Bijzonder Onderzoeksfonds UGent; Instituto de Salud Carlos III; Menzies Centre for Australian Studies, King's College London, University of London; Sixth Framework Programme; University of California, Irvine; University of California, San Francisco; University of California, San Diego; University of California, Davis; University of California, Los Angeles; Genentech; National Institutes of Health; Vetenskapsrådet; Arizona Biomedical Research Commission; Fundación Ramón Areces; UK Dementia Research Institute; Instituut Born-Bunge; IXICO; Hjartavernd; Biogen; Marcus och Amalia Wallenbergs minnesfond; Generalitat de Catalunya; Universitat Autònoma de Barcelona; Ministerio de Economía y Competitividad; Erasmus Medisch Centrum; University College London Hospitals NHS Foundation Trust; Mutuelle Générale de l'Education Nationale; Academy of Finland; Servier; Swedish Brain Power; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; North Bristol NHS Trust; Universiteit Antwerpen; Universidad Autónoma de Madrid; Kuopion Yliopistollinen Sairaala; Karolinska Institutet; Fonds Wetenschappelijk Onderzoek; South London and Maudsley NHS Foundation Trust; Belgian Federal Science Policy Office; National Center for Advancing Translational Sciences; Bundesministerium für Bildung und Forschung; AXA Research Fund; Ministero della Salute; H. Lundbeck A/S; Institut National de la Santé et de la Recherche Médicale; Deutsche Forschungsgemeinschaft; Cardiff University; University of Nottingham; Brigham Young University; Fondation pour la Recherche sur Alzheimer; Canadian Institutes of Health Research; European Commission; BioClinica; Newcastle University; Universitat de Barcelona; King's College London; Office of Research and Development; Parkinson's UK; Vlaamse regering; National Institute for Health and Care Research; Stichting MS Research; University of Southampton; Alzheimer's Society; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas; Agence Nationale de la Recherche; Wellcome Trust; Arizona Department of Health Services; Johns Hopkins University; Development of Innovative Strategies for a Transdisciplinary approach to ALZheimer's disease; CurePSP; Northern California Institute for Research and Education; Universität des Saarlandes; Rush University; Centro de Biología Molecular Severo Ochoa; Motor Neurone Disease Association; Novartis Pharmaceuticals Corporation; ZonMw; University of Cambridge; Stockholms Läns Landsting; University of Pittsburgh; Pfizer; EU Joint Programme – Neurodegenerative Disease Research; University of Washington; BrightFocus Foundation; Fondazione Cassa di Risparmio di Pistoia e Pescia; Alzheimer's Association; Northwestern University; Medical Research Council; Mayo Foundation for Medical Education and Research; Emory University; Universidad de Navarra; U.S. Department of Veterans Affairs; Fondation de France; University of Pennsylvania; Sanofi; Eisai; University of Southern California; U.S. Department of Defense; Hersenstichting; Eli Lilly and Company; York University; Vanderbilt University; GlaxoSmithKline; Mayo Clinic; Queen's University; University of Miami; Massachusetts General Hospital; Agence Française de Sécurité Sanitaire des Produits de Santé; Meso Scale Diagnostics; Fondation pour la Recherche Médicale; Bristol-Myers Squibb","keywords":"TREM2; Nonsynonymous substitution; Biology; Minor allele frequency; Genetics; Genome-wide association study; Microglia; Alzheimer's disease; Genotyping; Allele; Gene; Genotype; Allele frequency; Disease; Single-nucleotide polymorphism; Immunology; Genome; Immune system; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03495807231275978,"score_gpt":0.2946570760368707,"score_spread":0.2596990037241109,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}