{"id":"W2592587564","doi":"10.3390/ijms18030585","title":"Strategies for Overcoming Resistance in Tumours Harboring BRAF Mutations","year":2017,"lang":"en","type":"review","venue":"International Journal of Molecular Sciences","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Nova Scotia Health Authority; Dalhousie University","funders":"","keywords":"Kinase; Acquired resistance; Targeted therapy; Cancer research; Melanoma; MAPK/ERK pathway; Effector; Cancer; Colorectal cancer; Medicine; Mutation; Drug resistance; Bioinformatics; Biology; Gene; Immunology; Internal medicine; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004052128,0.0006645544,0.0009222966,0.002098367,0.0002614579,0.0007022487,0.000735365,0.0009240435,0.003490894],"category_scores_gemma":[0.0004932858,0.0001954157,0.0006781818,0.0007552239,0.0003875489,0.0009846085,0.0005237415,0.002215132,0.001538779],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004031073,"about_ca_system_score_gemma":0.0005230912,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005194333,"about_ca_topic_score_gemma":0.001223603,"domain_scores_codex":[0.9998521,0.00002657375,0.0000198181,0.00002279899,0.00005942797,0.00001927437],"domain_scores_gemma":[0.9998519,0.00006379004,0.00002491031,0.000006292364,0.00003638143,0.00001671808],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007476224,0.0001938253,0.0002917381,0.01611265,0.0001106897,0.0005186134,0.00009327552,0.0005399321,0.006570139,0.005088496,0.02235616,0.9480498],"study_design_scores_gemma":[0.00002708515,0.0001905226,0.0009755382,0.002621242,0.0001100341,0.002732717,0.0000722265,0.00015133,0.002023834,0.002229881,0.9888439,0.00002162817],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0004040565,0.9964545,0.0004578347,0.0005043886,0.0002567813,0.00001419423,0.00002422929,0.00002182654,0.001862338],"genre_scores_gemma":[0.002439123,0.9952084,0.0006298458,0.0003549447,0.0001710257,0.00001836006,0.00005718173,0.000003458614,0.001117608],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003490894,"threshold_uncertainty_score":0.01167822,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07573742879583725,"score_gpt":0.3929465407020033,"score_spread":0.3172091119061661,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}