{"id":"W2592596297","doi":"10.1128/msphere.00056-17","title":"Staurosporine Induces Filamentation in the Human Fungal Pathogen Candida albicans via Signaling through Cyr1 and Protein Kinase A","year":2017,"lang":"en","type":"article","venue":"mSphere","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; Government of Canada; National Institutes of Health; National Institute of Allergy and Infectious Diseases; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Staurosporine; Filamentation; Candida albicans; Virulence; Biology; Corpus albicans; Phenotypic switching; Microbiology; Fungal protein; Pathogen; Virulence factor; Cell biology; Signal transduction; Yeast; Protein kinase C; Phenotype; Genetics; Gene; Saccharomyces cerevisiae","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001154744,0.0001652944,0.00008439636,0.000173333,0.0001610495,0.0002379761,0.0001317461,0.0001971172,0.001744471],"category_scores_gemma":[0.00008720437,0.00007767739,0.0002467856,0.0001243243,0.0001136998,0.00009451451,0.0001277585,0.0005108658,0.0003232284],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003133033,"about_ca_system_score_gemma":0.0003249231,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0012655,"about_ca_topic_score_gemma":0.001980848,"domain_scores_codex":[0.999925,0.00001502493,0.00000615244,0.0000101671,0.00001986903,0.00002363123],"domain_scores_gemma":[0.9999646,0.000007192722,0.000007606047,0.000005032356,0.000004777889,0.00001073514],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003187095,0.00007349112,0.0002353504,0.00003976229,0.000005360103,0.00005312746,0.0000123677,0.00008308247,0.9956121,0.0002208447,0.0002273313,0.003118418],"study_design_scores_gemma":[0.00004128201,0.0004514134,0.008625561,0.00000819694,0.000009604017,0.000150515,0.00003519106,0.000882838,0.9867264,0.00008446552,0.002981078,0.000003477966],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9917528,0.002254165,0.000922896,0.0003586436,0.00004229146,0.00003886916,0.000713286,0.00008066268,0.003836468],"genre_scores_gemma":[0.9940002,0.001203431,0.001007325,0.0000997584,0.000008010544,0.00003379967,0.0006076878,0.000008729487,0.003031082],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001744471,"threshold_uncertainty_score":0.005835891,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03696148957810639,"score_gpt":0.32684641459213,"score_spread":0.2898849250140236,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}