{"id":"W2592609832","doi":"10.1111/apha.12872","title":"Calcium‐dependent Nedd4‐2 upregulation mediates degradation of the cardiac sodium channel Nav1.5: implications for heart failure","year":2017,"lang":"en","type":"article","venue":"Acta Physiologica","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"National Natural Science Foundation of China; Fundamental Research Funds for the Central Universities; National Science Foundation","keywords":"Downregulation and upregulation; Calcium; Nav1.5; Degradation (telecommunications); Sodium channel; Heart failure; NAV1; Calcium channel; Chemistry; Internal medicine; Cardiology; Medicine; Sodium; Biochemistry; Engineering; Electronic engineering","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001441869,0.0001587246,0.0004048081,0.00003014938,0.0006728473,0.00001649225,0.0002239692,0.0001760137,0.00001388739],"category_scores_gemma":[0.0003931034,0.0001005038,0.0003719361,0.00006124369,0.0002295129,0.0001144587,0.0001132207,0.0001601634,0.000005797373],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004005594,"about_ca_system_score_gemma":0.00009179957,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002994812,"about_ca_topic_score_gemma":0.000004677273,"domain_scores_codex":[0.9990286,0.00007180214,0.0002230581,0.0003094127,0.0001112816,0.0002558933],"domain_scores_gemma":[0.9983858,0.0001647597,0.0002870611,0.0009170513,0.000174555,0.00007076553],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000179826,0.00006307881,0.002942914,0.00003960772,0.0001036479,1.883631e-7,0.00005029152,0.00004116458,0.9885906,0.0009101264,0.006547134,0.0005314479],"study_design_scores_gemma":[0.000571258,0.000294413,0.8950332,0.00002724549,0.000148302,0.000009037576,0.00003838845,0.00009523459,0.09695704,0.004934035,0.001761591,0.0001302195],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9779219,0.0001159252,0.00007484351,0.02030534,0.0003213676,0.0009543467,0.0001124261,0.00004173671,0.0001521219],"genre_scores_gemma":[0.9981326,0.00004692907,0.0002408038,0.0003770043,0.000517532,0.0002167489,0.0001990388,0.00001436175,0.0002549181],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8920903,"threshold_uncertainty_score":0.5175065,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02725287323293915,"score_gpt":0.2952451350992765,"score_spread":0.2679922618663373,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}