{"id":"W2592743355","doi":"10.1158/1538-7445.crc16-a23","title":"Abstract A23: Rare variants in the FAT1 gene may predispose to familial colorectal cancer","year":2017,"lang":"en","type":"article","venue":"Cancer Research","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Pedigree chart; Genetics; Colorectal cancer; Exome; Germline mutation; Medicine; Germline; Population; Genetic predisposition; Cohort; Cancer; Exome sequencing; Biology; Oncology; Internal medicine; Mutation; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002768378,0.0007884206,0.0003997009,0.001239368,0.00050667,0.0004421738,0.0004260267,0.0006034252,0.01021898],"category_scores_gemma":[0.001264141,0.0002346321,0.0004364995,0.0009120274,0.0002766602,0.0001311024,0.0004150144,0.0004933886,0.00106334],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002659761,"about_ca_system_score_gemma":0.0002326291,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004688832,"about_ca_topic_score_gemma":0.003897054,"domain_scores_codex":[0.9997149,0.00004335716,0.00002825381,0.0001066861,0.00007426656,0.00003252514],"domain_scores_gemma":[0.9995744,0.0001265727,0.0001427503,0.00003324862,0.0000417119,0.00008139278],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.005385649,0.0004254112,0.5143284,0.0007491409,0.001800051,0.07210076,0.001316159,0.002615441,0.3305252,0.002054998,0.007879831,0.06081888],"study_design_scores_gemma":[0.0002232416,0.0007970782,0.8982225,0.0001607065,0.0008569692,0.0589663,0.0003320717,0.002999752,0.02305343,0.001155366,0.01316382,0.00006875314],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942124,0.0006190194,0.001586143,0.0001642822,0.00003600819,0.00003156815,0.001765205,0.0001501956,0.001435006],"genre_scores_gemma":[0.9966956,0.0002495823,0.0009744478,0.00006029522,0.00002698401,0.00002206415,0.0006741137,0.00003888873,0.00125799],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01021898,"threshold_uncertainty_score":0.03418589,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1185169197165801,"score_gpt":0.4471477067550161,"score_spread":0.328630787038436,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}